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ACY-957

Name: ACY-957
Brand: TargetMol
SKU: T10245
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10245Cas No. 1609389-52-7

Alias HDAC Inhibitor C001

ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.

ACY-957

🥰Excellent

Purity: 99.79%

Catalog No. T10245Alias HDAC Inhibitor C001Cas No. 1609389-52-7

ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
2 mg	$146	In Stock	In Stock
5 mg	$255	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$479	In Stock	In Stock
50 mg	$679	In Stock	In Stock
100 mg	$892	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$279	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.79%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.
Targets&IC50	HDAC2:18 nM, HDAC3:1300 nM, HDAC1:7 nM
In vitro	ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50 values of 7 nM for HDAC1, 18 nM for HDAC2, and 1300 nM for HDAC3, showing no inhibition of HDAC4/5/6/7/8/9. It exhibits an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors [1].
Synonyms	HDAC Inhibitor C001

Chemical Properties

Molecular Weight	429.54
Formula	C₂₄H₂₃N₅OS
Cas No.	1609389-52-7
Smiles	Nc1ccc(cc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1)-c1cccs1
Relative Density.	1.338 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (116.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3281 mL	11.6404 mL	23.2807 mL	116.4036 mL
5 mM	0.4656 mL	2.3281 mL	4.6561 mL	23.2807 mL
10 mM	0.2328 mL	1.1640 mL	2.3281 mL	11.6404 mL
20 mM	0.1164 mL	0.5820 mL	1.1640 mL	5.8202 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3281 mL
100 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc