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ACY-957

Name: ACY-957
Brand: TargetMol
SKU: T10245
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10245Cas No. 1609389-52-7

Alias HDAC Inhibitor C001

ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.

ACY-957

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Purity: 99.79%

Catalog No. T10245Alias HDAC Inhibitor C001Cas No. 1609389-52-7

ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
2 mg	$146	In Stock	In Stock
5 mg	$255	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$479	In Stock	In Stock
50 mg	$679	In Stock	In Stock
100 mg	$892	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$279	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.
Targets&IC50	HDAC3:1300 nM, HDAC1:7 nM, HDAC2:18 nM
In vitro	ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50 values of 7 nM for HDAC1, 18 nM for HDAC2, and 1300 nM for HDAC3, showing no inhibition of HDAC4/5/6/7/8/9. It exhibits an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors [1].
Synonyms	HDAC Inhibitor C001

Chemical Properties

Molecular Weight	429.54
Formula	C₂₄H₂₃N₅OS
Cas No.	1609389-52-7
Smiles	Nc1ccc(cc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1)-c1cccs1
Relative Density.	1.338 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (193.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3281 mL	11.6404 mL	23.2807 mL	116.4036 mL
5 mM	0.4656 mL	2.3281 mL	4.6561 mL	23.2807 mL
10 mM	0.2328 mL	1.1640 mL	2.3281 mL	11.6404 mL
20 mM	0.1164 mL	0.5820 mL	1.1640 mL	5.8202 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3281 mL
100 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc