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Abacavir monosulfate

Catalog No. T61679 CAS 216699-07-9

Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].

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Abacavir monosulfate, CAS 216699-07-9

Pack Size	Availability	Price/USD
5 mg	35 days	$ 110.00
10 mg	35 days	$ 210.00
25 mg	35 days	$ 483.00
50 mg	35 days	$ 786.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
In vitro	Abacavir monosulfate, at concentrations of 15 and 150 μM, exhibits diverse biological activities against prostate cancer cell lines, including growth inhibition, cell cycle alteration, senescence induction, and modulation of LINE-1 mRNA expression over a period of 0-120 hours [1]. Furthermore, it significantly reduces cell migration and invasion after an 18-hour treatment period at the same concentrations [1]. Additionally, in cell proliferation assays involving the PC3, LNCaP, and WI-38 cell lines, abacavir demonstrated a dose-dependent inhibition of growth. Cell cycle analysis revealed a pronounced accumulation of cells in the S phase, with an observed increase in the G2/M phase for PC3 cells when treated with 150 μM for periods ranging from 0 to 120 hours. Both cell migration and invasion assays reported considerable reductions in these processes in PC3 and LNCaP cells treated with 15 and 150 μM for 18 hours [1]. Moreover, abacavir monosulfate has been shown to induce fat apoptosis [4].
In vivo	Abacavir monosulfate administered in varying doses (0-7.5 μg/mL, 100 μL intrascrotally or 100 and 200 mg/kg orally for 4 hours) demonstrated a dose-dependent enhancement in thrombus formation [2]. Further, a combination treatment of Abacavir monosulfate (50 mg/kg/day) and Decitabine (0.1 mg/kg/day) via intraperitoneal injection for 14 days was found to inhibit tumor growth and extend survival in mice bearing high-risk medulloblastoma [3]. The first animal model utilized male C57BL/6 mice, either wild-type or P2rx7 homozygous knockout, aged 9-weeks and weighing 22-30 g, to study thrombosis [2]. The second model employed NSG TM mice implanted with patient-derived xenograft cells from Group 3 non-WNT/non-SHH or SHH/TP53-mutated medulloblastoma to assess the treatment’s efficacy on tumor growth and survival enhancement [3].

Molecular Weight	384.41
Formula	C14H20N6O5S
CAS No.	216699-07-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Abacavir monosulfate 216699-07-9 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.