Siglec-10 Protein, Cynomolgus, Recombinant (His)

Name: Siglec-10 Protein, Cynomolgus, Recombinant (His)
Brand: TargetMol
SKU: TMPK-00531
Rating: 4.5 (1 reviews)

(Synonyms: SLG2, SIGLEC10, PRO940, MGC126774) Copy Product Info

Synonyms: SLG2, SIGLEC10, PRO940, MGC126774

Catalog No. TMPK-00531 Copy Product Info

Siglec-10 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 59.90 kDa and the accession number is A0A2K5WBX8.

Pack Size	Price	USA Stock	Global Stock
10 µg	$92	7-10 days	7-10 days
20 µg	$148	7-10 days	7-10 days
50 µg	$289	7-10 days	7-10 days
100 µg	$487	7-10 days	7-10 days
200 µg	$883	7-10 days	7-10 days
500 µg	$1,950	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Cynomolgus Siglec-10, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Siglec-10 Antibody, hFc Tag with the EC50 of 17.7ng/ml determined by ELISA.
Description	Siglec-10 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 59.90 kDa and the accession number is A0A2K5WBX8.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-His
Accession Number	A0A2K5WBX8
Construction	Thr17-Asn552
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in 25 mM MES, 150 mM NaCl, 0.5M Arginine (pH 5.0).
Synonyms	SLG2, SIGLEC10, PRO940, MGC126774
Research Background	Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.

Chemical Properties

Molecular Weight

59.90 kDa (predicted). Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.