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SAP15
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Catalog No. TP2705Cas No. 1403753-45-6
Alias Synthetic anti-inflammatory peptide 15
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic peptide composed of 15 amino acids, derived from human beta-defensin 3, with the ability to penetrate cells and mitigate intracellular inflammation. It achieves its anti-inflammatory effects by blocking the phosphorylation of HDAC5, which in turn reduces NF-κB p65 phosphorylation. In macrophages stimulated with LPS, SAP15 suppresses the phosphorylation of both HDAC5 and NF-κB p65, demonstrating potent anti-inflammatory actions. Furthermore, treatment with SAP15 in LPS-induced chondrocytes elevates aggrecan and type II collagen levels while reducing osteocalcin expression. This peptide is valuable for exploring inflammation regulation and the development of anti-inflammatory therapies in biomaterials.
SAP15
😃Good
Catalog No. TP2705Alias Synthetic anti-inflammatory peptide 15Cas No. 1403753-45-6
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic peptide composed of 15 amino acids, derived from human beta-defensin 3, with the ability to penetrate cells and mitigate intracellular inflammation. It achieves its anti-inflammatory effects by blocking the phosphorylation of HDAC5, which in turn reduces NF-κB p65 phosphorylation. In macrophages stimulated with LPS, SAP15 suppresses the phosphorylation of both HDAC5 and NF-κB p65, demonstrating potent anti-inflammatory actions. Furthermore, treatment with SAP15 in LPS-induced chondrocytes elevates aggrecan and type II collagen levels while reducing osteocalcin expression. This peptide is valuable for exploring inflammation regulation and the development of anti-inflammatory therapies in biomaterials.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic peptide composed of 15 amino acids, derived from human beta-defensin 3, with the ability to penetrate cells and mitigate intracellular inflammation. It achieves its anti-inflammatory effects by blocking the phosphorylation of HDAC5, which in turn reduces NF-κB p65 phosphorylation. In macrophages stimulated with LPS, SAP15 suppresses the phosphorylation of both HDAC5 and NF-κB p65, demonstrating potent anti-inflammatory actions. Furthermore, treatment with SAP15 in LPS-induced chondrocytes elevates aggrecan and type II collagen levels while reducing osteocalcin expression. This peptide is valuable for exploring inflammation regulation and the development of anti-inflammatory therapies in biomaterials. |
| Synonyms | Synthetic anti-inflammatory peptide 15 |
| Molecular Weight | 1767.16 |
| Formula | C68H131N31O18S3 |
| Cas No. | 1403753-45-6 |
| Smiles | [C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC(CN)=O)=O)CS)=O)CO)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CS)=O)CS)=O)CCCNC(=N)N)=O)(C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N |
| Sequence | Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys |
| Sequence Short | GKCSTRGRKCCRRKK |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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