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GluR6 antagonist-1

Name: GluR6 antagonist-1
Brand: TargetMol
SKU: T9723
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9723Cas No. 323176-64-3

GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.

GluR6 antagonist-1

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Purity: 99.89%

Catalog No. T9723Cas No. 323176-64-3

GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$50	In Stock	In Stock
25 mg	$84	In Stock	In Stock
50 mg	$125	In Stock	In Stock
100 mg	$186	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

GluR6 antagonist-1 AI Summary

GluR6 antagonist-1 exhibits a variety of bioactivities based on the research data: it inhibits ELG1-dependent DNA repair, Importin beta complex formation, and Importin beta complex dissociation induced by RanGTP. Additionally, it acts as an inhibitor of Polymerase Iota and shows activity as both an inhibitor and activator of firefly luciferase. The compound also inhibits the binding or entry of the Marburg Virus into cells and the Hepatitis C Virus (HCV). Moreover, it functions as an inverse agonist for the GLP-1 receptor and inhibits Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.

Chemical Properties

Molecular Weight	302.78
Formula	C₁₅H₁₁ClN₂OS
Cas No.	323176-64-3
Smiles	ClC=1C=2C(SC1C(NCC=3C=CC=NC3)=O)=CC=CC2
Relative Density.	1.380 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (181.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3027 mL	16.5136 mL	33.0273 mL	165.1364 mL
5 mM	0.6605 mL	3.3027 mL	6.6055 mL	33.0273 mL
10 mM	0.3303 mL	1.6514 mL	3.3027 mL	16.5136 mL
20 mM	0.1651 mL	0.8257 mL	1.6514 mL	8.2568 mL
50 mM	0.0661 mL	0.3303 mL	0.6605 mL	3.3027 mL
100 mM	0.0330 mL	0.1651 mL	0.3303 mL	1.6514 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc