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Gontivimab (Synonyms: VR-465, VR465, ALX-0171, ALX0171)

Catalog No. T77027 Copy Product Info
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Gontivimab (ALX-0171) is a trivalent nanobody targeting the hRSV fusion (F) protein with anti-RSV antiviral properties for the study of respiratory syncytial virus infections.

Gontivimab

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Catalog No. T77027
Synonyms VR-465, VR465, ALX-0171, ALX0171

Gontivimab (ALX-0171) is a trivalent nanobody targeting the hRSV fusion (F) protein with anti-RSV antiviral properties for the study of respiratory syncytial virus infections.

Gontivimab
Cas No. 1257358-38-5
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$195In StockIn Stock
5 mg$483In StockIn Stock
10 mg$692-In Stock
25 mg$1,080-In Stock
50 mg$1,490-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Gontivimab (ALX-0171) is a trivalent nanobody targeting the hRSV fusion (F) protein with anti-RSV antiviral properties for the study of respiratory syncytial virus infections.
Targets&IC50
RSV A strains:0.1 nM
In vitro
Gontivimab (0-100,000 nM) exhibited antiviral effects with IC50 values of 0.1 nM and 0.4 nM against RSV-A and RSV-B 18537 strains, respectively.[1] Gontivimab binds to antigenic site II of the F protein.[1]
Gontivimab binds to antigenic site II of the F protein.[1]
In vivo
Gontivimab (1-68 mg/kg; administered intranasally or by nebulization) reduces RSV load in the nasal cavity and lungs of rats.[1] Gontivimab has been shown to reduce RSV load in the nasal cavity and lungs of rats. [1]
SynonymsVR-465, VR465, ALX-0171, ALX0171
Reactivity
Virus
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetRSV-F
Chemical Properties
Molecular Weight42.14 kDa
Cas No.1257358-38-5
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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