Anti-PPAR alpha/PPARA Polyclonal Antibody

Name: Anti-PPAR alpha/PPARA Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01564
Rating: 4.5 (1 reviews)

(Synonyms: PPAR-α, PPARα, PPAR-alpha, PPARalpha, Ppar, peroxisome proliferator-activated receptor α, peroxisome proliferator-activated receptor alpha, Nr1c1, AW742785, 4933429D07Rik) Copy Product Info

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Synonyms: PPAR-α, PPARα, PPAR-alpha, PPARalpha, Ppar, peroxisome proliferator-activated receptor α, peroxisome proliferator-activated receptor alpha, Nr1c1, AW742785, 4933429D07Rik

Catalog No. TMAB-01564 Copy Product Info

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Anti-PPAR alpha/PPARA Polyclonal Antibody is a Rabbit antibody targeting PPAR alpha/PPARA. Anti-PPAR alpha/PPARA Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.

Anti-PPAR alpha/PPARA Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-PPAR alpha/PPARA Polyclonal Antibody is a Rabbit antibody targeting PPAR alpha/PPARA. Anti-PPAR alpha/PPARA Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Synonyms	PPAR-α, PPARα, PPAR-alpha, PPARalpha, Ppar, peroxisome proliferator-activated receptor α, peroxisome proliferator-activated receptor alpha, Nr1c1, AW742785, 4933429D07Rik
Ig Type	IgG
Reactivity	Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Horse,Rabbit,Sheep)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus.
Tissue Specificity	Skeletal muscle, liver, heart and kidney.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors (PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human PPAR alpha
Antigen Species	Human
Gene Name	Ppara
Gene ID	5465
Protein Name	Peroxisome proliferator-activated receptor alpha
Uniprot ID	Q07869
Biology Area	Metabolism of lipids and lipoproteins,Response to hypoxia,Nuclear hormone receptors,Metabolism,Zinc Finger,Fatty acids,Lipid metabolism,Mitochondrial transcription,Hypoxia,Mitochondrial Biogenesis,Fatty acid oxidation,Obesity
Function	Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.