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Pateclizumab
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Catalog No. T77366Cas No. 1202526-59-7
Alias RG7416, RG 7416, PRO283698, PRO 283698, MLTA3698A, MLTA 3698A
Pateclizumab (MLTA3698A) is a humanized monoclonal antibody targeting lymphotoxin α (LTα), which can be used to study rheumatoid arthritis.
Pateclizumab
Pateclizumab
😃Good
Catalog No. T77366Alias RG7416, RG 7416, PRO283698, PRO 283698, MLTA3698A, MLTA 3698ACas No. 1202526-59-7
Pateclizumab (MLTA3698A) is a humanized monoclonal antibody targeting lymphotoxin α (LTα), which can be used to study rheumatoid arthritis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $415 | - | In Stock | |
| 5 mg | $1,245 | - | In Stock | |
| 10 mg | $1,992 | - | In Stock | |
| 25 mg | $3,386 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.96% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
| Description | Pateclizumab (MLTA3698A) is a humanized monoclonal antibody targeting lymphotoxin α (LTα), which can be used to study rheumatoid arthritis. |
| In vitro | Pateclizumab is a human immunoglobulin G1 (IgG1) monoclonal antibody. By blocking the binding of Lα3 to TNFRII and Lα1β2 to Lβr, the IC50 was 0.29 nM and 0.31 nM, respectively. [1] |
| In vivo | In cynomolgus monkeys treated with pateclizumab (5, 15, 50 mg/kg), the ratio of fetal to maternal serum concentration was 0.73% on GD 50 and 61% on GD 139. Taking Pateclizumab between the 20th and 132nd days of gestation does not induce maternal or fetal developmental toxicity. [1] |
| Synonyms | RG7416, RG 7416, PRO283698, PRO 283698, MLTA3698A, MLTA 3698A |
| Reactivity | Human |
| Verified Activity | Immobilized human TNFSF1/TNFb Protein (His) at 2 μg/mL can bind Pateclizumab. The EC50 is 0.01351 μg/mL. |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFSF1/TNFb/ LT alpha |
| Molecular Weight | 144.9 kDa |
| Cas No. | 1202526-59-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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