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Salvianolic Acid C

Name: Salvianolic Acid C
Brand: TargetMol
SKU: T3149
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3149Cas No. 115841-09-3

Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.

Salvianolic Acid C

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Purity: 99.76%

Catalog No. T3149Cas No. 115841-09-3

Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$463	-	In Stock
200 mg	$666	-	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.76%

Color:White to Yellow

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COA

Product Introduction

Salvianolic Acid C AI Summary

Salvianolic Acid C exhibits a range of bioactivities including potent inhibition of xanthine oxidase with an IC50 value of 8260.0 nM, and notable antioxidant activity as evidenced by DPPH radical scavenging with an IC50 of 6870.0 nM and a superoxide anion scavenging activity of 37.82% in LPS-induced mouse RAW264.7 cells at 10 μM after 24 hours. The compound also demonstrates cytotoxic activity against mouse RAW264.7 cells, with a cytotoxic effect greater than 85.0% at concentrations between 1 to 10 μM over 24 hours, as measured by the MTT assay. In antiviral assays, Salvianolic Acid C inhibits the spike glycoprotein S of SARS-CoV-2 in pseudovirus-infected human 293T/ACE2 cells with an IC50 of 3850.0 nM. It shows a selectivity index greater than 25.97, indicating preferential inhibition of viral infection over cytotoxicity (CC50 > 100000.0 nM). Additionally, it achieves 98.3% inhibition of pseudovirus infection in human HEK293T cells expressing ACE2 at 10 μM concentration after 48 hours, with significant inhibition (80.25%) even at a higher concentration of 40 μM. Furthermore, Salvianolic Acid C acts as a P2Y12 receptor antagonist with a Ki value of 15600.0 nM, demonstrating its ability to displace [3H]2MeSADP from the human P2Y12 receptor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.
Targets&IC50	CYP2J2:5.75 μM (Ki), CYP2C8:4.82 μM (Ki)
In vitro	METHODS: Human periodontal stem cells hPDLSCs were pretreated with Salvianolic acid C (0-5 mM) for 1 h, then cultured with LPS (1 µg/mL) for 24 h. Cytokines were detected using ELISA kits. RESULTS: Salvianolic acid C treatment significantly inhibited the expression of TNFα, IL-6 and IL-1β in a dose-dependent manner. [1] METHODS: HEK293T cells stably expressing human-ACE2 were treated with Salvianolic acid C (0-100 µM), and viral entry was studied using the SARS-CoV-2 HSCs pseudovirus (PsV) system. RESULTS: Salvianolic acid C inhibited SARS-CoV-2 PsV entry on 293T/ACE2 cells with an IC50 of 3.85 µM.[2]
In vivo	METHODS: To investigate the effects on liver injury, Salvianolic acid C (5-20 mg/kg) was intraperitoneally injected into C57BL/6J mice with CCl4-induced hepatic fibrosis once a day for six days, followed by APAP (400 mg/kg) to induce liver injury. RESULTS: Salvianolic acid C protects hepatocytes from APAP-induced injury by attenuating mitochondrial oxidative stress, inflammatory response, and cystatinase-mediated anti-apoptotic effects via inhibition of the Keap1/Nrf2/HO-1 signaling axis. [3]

Chemical Properties

Molecular Weight	492.43
Formula	C₂₆H₂₀O₁₀
Cas No.	115841-09-3
Smiles	OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2oc(cc12)-c1ccc(O)c(O)c1
Relative Density.	1.571g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (111.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.5 mg/mL (11.17 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0307 mL	10.1537 mL	20.3075 mL	101.5373 mL
5 mM	0.4061 mL	2.0307 mL	4.0615 mL	20.3075 mL
10 mM	0.2031 mL	1.0154 mL	2.0307 mL	10.1537 mL
20 mM	0.1015 mL	0.5077 mL	1.0154 mL	5.0769 mL
50 mM	0.0406 mL	0.2031 mL	0.4061 mL	2.0307 mL
100 mM	0.0203 mL	0.1015 mL	0.2031 mL	1.0154 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc