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Capsiate

Name: Capsiate
Brand: TargetMol
SKU: TN2429
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2429Cas No. 205687-01-0

Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.

Capsiate

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Purity: 99.24%

Catalog No. TN2429Cas No. 205687-01-0

Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.

Pack Size	Price	Availability
1 mg	$73	In Stock
5 mg	$189	In Stock
10 mg	$289	In Stock

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Purity:99.24%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.
Targets&IC50	TRPV1:290 nM(EC50)
In vitro	Capsiate elicits current responses in HEK293 cells expressing TRPV1[3]. Additionally, Capsiate (5 to 25 µM) inhibits Src and VEGF-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs)[1].
In vivo	Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice.[3] Topical application of Capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.[3] Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.[4]

Chemical Properties

Molecular Weight	306.4
Formula	C₁₈H₂₆O₄
Cas No.	205687-01-0
Smiles	C(OC(CCCC/C=C/C(C)C)=O)C1=CC(OC)=C(O)C=C1
Relative Density.	1.053 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (293.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2637 mL	16.3185 mL	32.6371 mL	163.1854 mL
5 mM	0.6527 mL	3.2637 mL	6.5274 mL	32.6371 mL
10 mM	0.3264 mL	1.6319 mL	3.2637 mL	16.3185 mL
20 mM	0.1632 mL	0.8159 mL	1.6319 mL	8.1593 mL
50 mM	0.0653 mL	0.3264 mL	0.6527 mL	3.2637 mL
100 mM	0.0326 mL	0.1632 mL	0.3264 mL	1.6319 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc