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Metoclopramide hydrochloride

Name: Metoclopramide hydrochloride
Brand: TargetMol
SKU: T1069
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1069Cas No. 7232-21-5

Alias Metoclopramide HCl, Maxolon

Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.

Metoclopramide hydrochloride

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Purity: 99.99%

Catalog No. T1069Alias Metoclopramide HCl, MaxolonCas No. 7232-21-5

Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$33	In Stock	In Stock
25 mg	$50	In Stock	In Stock
50 mg	$71	In Stock	In Stock
100 mg	$92	In Stock	In Stock
200 mg	$147	In Stock	In Stock
500 mg	$243	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Metoclopramide hydrochloride AI Summary

Metoclopramide hydrochloride exhibits a broad range of bioactivities across different assays and biological models. It demonstrates antiplasmodial activity against Plasmodium falciparum W2 with a pIC25 value of 4.9, measured using the SYBR green assay over 72 hours. The compound shows specific potency as a Rab9 Promoter Activator at 5623.4 nM and exhibits an IC50 greater than 50000.0 nM as an Estrogen Receptor-beta Coactivator Binding Inhibitor. Additionally, it acts as a differential inhibitor of the proliferation of Plasmodium falciparum line W2 at 15848.9 nM, and inhibits MPP8 Chromodomain interactions with Methylated Histone Tails at a potency of 89125.1 nM, and HP1-beta Chromodomain interactions at 10000.0 nM. Among its notable activities, it inhibits Histone Lysine Methyltransferase G9a at 22.4 nM and the ERG Ets/DNA interaction at 50118.7 nM. In cellular assays, Metoclopramide hydrochloride significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 84.82% and 108.21% respectively at 10 µM. In a Wistar rat gastroparesis model, the compound improves gastric emptying by 41.0% at 10 mg/kg when administered intravenously post-meal, as measured after 15 minutes using a colorimetric method. Despite these activities, it shows very low efficacy in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), with an inhibition index of 0.02423 at a low MOI of 0.002 after 72 hours. Furthermore, Metoclopramide hydrochloride displays modest antifungal activity against Candida albicans (3.69% inhibition) and antibacterial activity against Klebsiella pneumoniae (10.19%), Pseudomonas aeruginosa (3.44%), Acinetobacter baumannii (16.26%), and Staphylococcus aureus MRSA (7.88%). However, it has negative inhibition rates against Cryptococcus neoformans (-1.39%) and Escherichia coli (-6.93%)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.
Targets&IC50	5-HT3 receptor:308 nM (IC50), D2 receptor:483 nM (IC50)
Synonyms	Metoclopramide HCl, Maxolon

Chemical Properties

Molecular Weight	336.26
Formula	C₁₄H₂₂ClN₃O₂·HCl
Cas No.	7232-21-5
Smiles	Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 62 mg/mL (184.38 mM), Sonication is recommended.

H2O: 61 mg/mL (181.41 mM), Sonication is recommended.

DMSO: 50 mg/mL (148.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9739 mL	14.8694 mL	29.7389 mL	148.6945 mL
5 mM	0.5948 mL	2.9739 mL	5.9478 mL	29.7389 mL
10 mM	0.2974 mL	1.4869 mL	2.9739 mL	14.8694 mL
20 mM	0.1487 mL	0.7435 mL	1.4869 mL	7.4347 mL
50 mM	0.0595 mL	0.2974 mL	0.5948 mL	2.9739 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4869 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc