Shopping Cart

Your shopping cart is currently empty

AMG 579

Name: AMG 579
Brand: TargetMol
SKU: T14217
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14217Cas No. 1227067-61-9

Alias AMG-579

AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).

AMG 579

🥰Excellent

Purity: 99.87%

Catalog No. T14217Alias AMG-579Cas No. 1227067-61-9

AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$39	In Stock	In Stock
5 mg	$67	In Stock	In Stock
10 mg	$107	In Stock	In Stock
25 mg	Preferential	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
Targets&IC50	PDE10A:0.1 nM
In vivo	AMG 579 statistically reduces PCP-induced behavior in rats within 2 hours. In the PCP-LMA model, the minimum effective dose of AMG 579 was 0.3 mg/kg. AMG 579 has an excellent oral bioavailability of 72% in dogs[1].
Synonyms	AMG-579

Chemical Properties

Molecular Weight	441.48
Formula	C₂₅H₂₃N₅O₃
Cas No.	1227067-61-9
Smiles	CC(=O)N1CCC(CC1)c1nccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Relative Density.	1.322 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37.8 mg/mL (85.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2651 mL	11.3255 mL	22.6511 mL	113.2554 mL
5 mM	0.4530 mL	2.2651 mL	4.5302 mL	22.6511 mL
10 mM	0.2265 mL	1.1326 mL	2.2651 mL	11.3255 mL
20 mM	0.1133 mL	0.5663 mL	1.1326 mL	5.6628 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL	2.2651 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc