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Anti-RASAL1 Polyclonal Antibody

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Catalog No. TMAB-12105

Anti-RASAL1 Polyclonal Antibody is a Rabbit antibody targeting RASAL1. Anti-RASAL1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-RASAL1 Polyclonal Antibody

Anti-RASAL1 Polyclonal Antibody

😃Good
Catalog No. TMAB-12105
Anti-RASAL1 Polyclonal Antibody is a Rabbit antibody targeting RASAL1. Anti-RASAL1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-RASAL1 Polyclonal Antibody is a Rabbit antibody targeting RASAL1. Anti-RASAL1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human,Rat (predicted:Mouse,Dog,Cow,Sheep)
Application
Recommended Dose
IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Tissue SpecificityHighly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundRas GTPase activating-like protein (RASAL) or RASAL1 is a member of the GAP1 family, and a Ca2+ sensor responding in-phase to repetitive Ca2+ signals by associating with the plasma membrane and deactivating Ras. It contains a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin-homology domain that is associated with a Bruton's tyrosine kinase motif. RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human RASAL1
Antigen Species
Human
Gene Name
RASAL1
Gene ID
Protein Name
RasGAP-activating-like protein 1
Uniprot ID
Function
Probable inhibitory regulator of the Ras-cyclic AMP pathway.
Chemical Properties
Molecular WeightTheoretical: 90 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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