Shopping Cart
Remove All
Your shopping cart is currently empty
1-Aminocyclobutanecarboxylic acid
Copy Product Info
😃Good
Catalog No. T22542Cas No. 22264-50-2
Alias ACBC
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
1-Aminocyclobutanecarboxylic acid
Copy Product Info😃Good
Purity: 99.94%
Catalog No. T22542Alias ACBCCas No. 22264-50-2
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $48 | In Stock | In Stock | |
| 50 mg | $73 | In Stock | In Stock | |
| 100 mg | $106 | In Stock | In Stock | |
| 500 mg | $269 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.94%
Appearance:solid
Color:White
Contact us for more batch information
Product Introduction
1-Aminocyclobutanecarboxylic acid AI Summary
1-Aminocyclobutanecarboxylic acid exhibits multi-faceted bioactivity across various assays. It shows in vitro inhibition of glycine at the NMDA receptor with an IC50 of 19,000 nM, and specifically in oocytes with an IC50 of 18,500 nM. In rat brain cortex membranes, it acts as a partial agonist at the glycine site of the NMDA receptor, potentiating [3H]Mk-801 binding by 53.0% relative to glycine in the presence of 5,7-dichlorokynurenic acid, and displaces [3H]glycine with a Ki value of 15,848.93 nM.
Beyond its effects on NMDA receptors, 1-Aminocyclobutanecarboxylic acid is notable for its inhibitory actions on several bio-targets: it inhibits the Menin-MLL interaction pivotal in MLL-related leukemias with a potency of 39,810.7 nM, Tau fibril formation and Thioflavin T binding at 12,589.3 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 79,432.8 nM, and Anthrax lethal toxin internalization at 12,589.3 nM. It also displays activity in the Cytochrome p450-cyp1a2 panel assay with an AC50 of 39,810.72 nM.
Additionally, 1-Aminocyclobutanecarboxylic acid significantly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, showing 95.93% and 131.14% inhibition respectively at a 10 µM substrate-inhibitor concentration, indicating potent effects on these transporters. Lastly, it inhibits ASCT2-mediated [3H]-D-serine uptake in rat hippocampal astrocytes at 1 mM concentration, reducing uptake by at least 25.0% within 5 minutes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1]. |
| Synonyms | ACBC |
| Molecular Weight | 115.13 |
| Formula | C5H9NO2 |
| Cas No. | 22264-50-2 |
| Smiles | NC1(CCC1)C(O)=O |
| Relative Density. | 1.541g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 25 mg/mL (217.15 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy 1-Aminocyclobutanecarboxylic acid | purchase 1-Aminocyclobutanecarboxylic acid | 1-Aminocyclobutanecarboxylic acid cost | order 1-Aminocyclobutanecarboxylic acid | 1-Aminocyclobutanecarboxylic acid chemical structure | 1-Aminocyclobutanecarboxylic acid formula | 1-Aminocyclobutanecarboxylic acid molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.