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Clotrimazole

Name: Clotrimazole
Brand: TargetMol
SKU: T0506
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0506Cas No. 23593-75-1

Alias FB 5097, BAY b 5097

Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.

Clotrimazole

🥰Excellent

Purity: 99.89%

Catalog No. T0506Alias FB 5097, BAY b 5097Cas No. 23593-75-1

Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.

Pack Size	Price	Availability
200 mg	$30	In Stock
500 mg	$45	In Stock
1 g	$53	In Stock
2 g	$74	In Stock
5 g	$118	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.89%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.
In vitro	Intradermal injection of Clotrimazole in mice stimulates capsaicin-sensitive and mustard oil-sensitive trigeminal neurons, inducing nocifensive behavior and thermal hyperalgesia. In TRPV1 knockout mice, Clotrimazole-induced pain behavior is inhibited by the TRPV1 antagonist BCTC [1,2,3,4-tetrahydro-6-trichloromethyl-pyrimidine-2-one].
In vivo	In the CRI-G1 whole-cell of a rat insulinoma cell line, Clotrimazole antagonizes ADP-ribose-activated and single-channel currents. Clotrimazole effectively and rapidly inhibits parasite growth across five different strains of the malignant malaria protozoan. In HEK-293 cells expressing recombinant human TRPM2, Clotrimazole inhibits ADP-ribose-activated currents. At 2 mM concentration, Clotrimazole completely suppresses parasite replication, resulting in the destruction of host cells. Furthermore, Clotrimazole at concentrations ranging from 3 mM to 30 mM entirely inhibits TRPM2-mediated currents.
Synonyms	FB 5097, BAY b 5097

Chemical Properties

Molecular Weight	344.84
Formula	C₂₂H₁₇ClN₂
Cas No.	23593-75-1
Smiles	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Relative Density.	1.1095 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.88 mg/mL (19.94 mM), Sonication is recommended.

Ethanol: 64 mg/mL (185.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8999 mL	14.4995 mL	28.9990 mL	144.9948 mL
5 mM	0.5800 mL	2.8999 mL	5.7998 mL	28.9990 mL
10 mM	0.2900 mL	1.4499 mL	2.8999 mL	14.4995 mL

Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.1450 mL	0.7250 mL	1.4499 mL	7.2497 mL
50 mM	0.0580 mL	0.2900 mL	0.5800 mL	2.8999 mL
100 mM	0.0290 mL	0.1450 mL	0.2900 mL	1.4499 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc