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ZM223

Name: ZM223
Brand: TargetMol
SKU: T13412
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13412Cas No. 2031177-48-5

Alias ZM-223

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

ZM223

🥰Excellent

Purity: 99.73%

Catalog No. T13412Alias ZM-223Cas No. 2031177-48-5

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

Pack Size	Price	Availability
1 mg	$117	In Stock
2 mg	$175	In Stock
5 mg	$268	In Stock
10 mg	$394	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
500 mg	$2,260	In Stock

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Batch Information

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Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
In vitro	ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1].
Synonyms	ZM-223

Chemical Properties

Molecular Weight	502.53
Formula	C₂₃H₁₇F₃N₄O₂S₂
Cas No.	2031177-48-5
Smiles	N(C(=O)C1=CC=C(C(F)(F)F)C=C1)C2=NC=3C(S2)=CC(NC(CSC4=CC=C(N)C=C4)=O)=CC3
Relative Density.	1.51 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (159.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9899 mL	9.9497 mL	19.8993 mL	99.4965 mL
5 mM	0.3980 mL	1.9899 mL	3.9799 mL	19.8993 mL
10 mM	0.1990 mL	0.9950 mL	1.9899 mL	9.9497 mL
20 mM	0.0995 mL	0.4975 mL	0.9950 mL	4.9748 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9899 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc