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ZM223

Name: ZM223
Brand: TargetMol
SKU: T13412
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13412Cas No. 2031177-48-5

Alias ZM-223

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

ZM223

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Purity: 99.73%

Catalog No. T13412Alias ZM-223Cas No. 2031177-48-5

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
2 mg	$175	-	In Stock
5 mg	$268	-	In Stock
10 mg	$394	-	In Stock
25 mg	$592	-	In Stock
50 mg	$828	-	In Stock
100 mg	$1,130	-	In Stock
500 mg	$2,260	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
In vitro	ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1].
Synonyms	ZM-223

Chemical Properties

Molecular Weight	502.53
Formula	C₂₃H₁₇F₃N₄O₂S₂
Cas No.	2031177-48-5
Smiles	N(C(=O)C1=CC=C(C(F)(F)F)C=C1)C2=NC=3C(S2)=CC(NC(CSC4=CC=C(N)C=C4)=O)=CC3
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (159.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9899 mL	9.9497 mL	19.8993 mL	99.4965 mL
5 mM	0.3980 mL	1.9899 mL	3.9799 mL	19.8993 mL
10 mM	0.1990 mL	0.9950 mL	1.9899 mL	9.9497 mL
20 mM	0.0995 mL	0.4975 mL	0.9950 mL	4.9748 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9899 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc