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EGFR-IN-47
Catalog No. T63185 Copy Product Info
Purity: 98.78%
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EGFR-IN-47 (compound 14aj) is a potent, fourth-generation, and orally active EGFR inhibitor. It specifically targets the EGFR L858R/T790M/C797S triple mutation with an IC50 of 0.01 uM. In NSCLC research, EGFR-IN-47 effectively overcomes C797S-mediated resistance to Osimertinib by inhibiting the phosphorylation of EGFR and its downstream mediators, subsequently inducing cell cycle arrest and apoptosis.
EGFR-IN-47
Copy Product Info😃Good
Catalog No. T63185
EGFR-IN-47 (compound 14aj) is a potent, fourth-generation, and orally active EGFR inhibitor. It specifically targets the EGFR L858R/T790M/C797S triple mutation with an IC50 of 0.01 uM. In NSCLC research, EGFR-IN-47 effectively overcomes C797S-mediated resistance to Osimertinib by inhibiting the phosphorylation of EGFR and its downstream mediators, subsequently inducing cell cycle arrest and apoptosis.
Cas No. 3034649-73-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $81 | - | In Stock | |
| 5 mg | $197 | - | In Stock | |
| 10 mg | $317 | - | In Stock | |
| 25 mg | $633 | - | In Stock | |
| 50 mg | $987 | - | In Stock |
In stock · Dispatch: USA[1-2d] Global[5-7d]
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.78%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EGFR-IN-47 (compound 14aj) is a potent, fourth-generation, and orally active EGFR inhibitor. It specifically targets the EGFR L858R/T790M/C797S triple mutation with an IC50 of 0.01 uM. In NSCLC research, EGFR-IN-47 effectively overcomes C797S-mediated resistance to Osimertinib by inhibiting the phosphorylation of EGFR and its downstream mediators, subsequently inducing cell cycle arrest and apoptosis. |
| Targets&IC50 | EGFR T790M:0.07 μM, EGFR L858R:0.07 μM, EGFR C797S:0.07 μM |
| In vitro | EGFR-IN-47 potently inhibits PC-9 cell growth (IC50 = 0.013 uM) and induces G0/G1 arrest [1]. |
| In vivo | Oral EGFR-IN-47 (10-40 mg/kg) shows significant efficacy in xenografts; rat PK reveals 66.05% bioavailability [1]. |
| Molecular Weight | 481.64 |
| Formula | C29H35N7 |
| Cas No. | 3034649-73-2 |
| Smiles | N1=CC=2C=C(N(C2N=C1NC3=CC=C(C=C3)N4CCN(C)CC4)C5CCCC5)CNC=6C=CC=CC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16.00 mg/mL (33.22 mM), Sonication is recommmended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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