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MDL 72527

Name: MDL 72527
Brand: TargetMol
SKU: T22965
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22965Cas No. 93565-01-6

Alias N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride

MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) is a polyamine oxidase (POA) inhibitor

MDL 72527

🥰Excellent

Purity: 98.98%

Catalog No. T22965Alias N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochlorideCas No. 93565-01-6

MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) is a polyamine oxidase (POA) inhibitor

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$263	In Stock
50 mg	$428	In Stock
100 mg	$639	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Purity:98.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) is a polyamine oxidase (POA) inhibitor
In vivo	In the absence of CRP, exposure of platelets to MDL-72527 did not significantly modify [Ca2+]i, P-selectin abundance, αIIbβ3 integrin abundance, ROS, annexin-V-binding, and forward scatter. The addition of 2-5 μg/ml CRP was followed by significant increase of [Ca2+]i, P-selectin abundance, αIIbβ3 integrin activation, ROS abundance, annexin-V-binding, and aggregation as well as a significant decrease of forward scatter, all effects significantly blunted or virtually abolished in the presence of MDL-72527. MDL-72527 is a powerful inhibitor of platelet activation, apoptosis and aggregation[1].
Synonyms	N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride

Chemical Properties

Molecular Weight	265.22
Formula	C₁₂H₂₂Cl₂N₂
Cas No.	93565-01-6
Smiles	C=C=CCNCCCCNCC=C=C.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (75.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7705 mL	18.8523 mL	37.7045 mL	188.5227 mL
5 mM	0.7541 mL	3.7705 mL	7.5409 mL	37.7045 mL
10 mM	0.3770 mL	1.8852 mL	3.7705 mL	18.8523 mL
20 mM	0.1885 mL	0.9426 mL	1.8852 mL	9.4261 mL
50 mM	0.0754 mL	0.3770 mL	0.7541 mL	3.7705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc