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Roluperidone

Name: Roluperidone
Brand: TargetMol
SKU: T15034
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15034Cas No. 359625-79-9

Alias MT-210, MIN-101, CYR-101

Roluperidone (CYR-101), a novel cyclic amide derivative, exhibits high equipotent affinities for 5-HT2A and σ2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively.

Roluperidone

🥰Excellent

Purity: 97.77%

Catalog No. T15034Alias MT-210, MIN-101, CYR-101Cas No. 359625-79-9

Roluperidone (CYR-101), a novel cyclic amide derivative, exhibits high equipotent affinities for 5-HT2A and σ2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$47	In Stock
10 mg	$79	In Stock
25 mg	$158	In Stock
50 mg	$257	In Stock
100 mg	$395	In Stock

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Purity:97.77%

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COA HPLC

Product Introduction

Bioactivity

Description	Roluperidone (CYR-101), a novel cyclic amide derivative, exhibits high equipotent affinities for 5-HT2A and σ2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively.
Targets&IC50	σ2 receptor:8.19 nM(ki), 5-HT2A:7.53 nM(ki)
In vitro	Roluperidone shows binding affinity for α1-adrenergic receptors. Which low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways and in calcium neuronal modulation[1].
Synonyms	MT-210, MIN-101, CYR-101

Chemical Properties

Molecular Weight	366.43
Formula	C₂₂H₂₃FN₂O₂
Cas No.	359625-79-9
Smiles	Fc1ccc(cc1)C(=O)CN1CCC(CN2Cc3ccccc3C2=O)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 33.33 mg/mL (90.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7290 mL	13.6452 mL	27.2903 mL	136.4517 mL
5 mM	0.5458 mL	2.7290 mL	5.4581 mL	27.2903 mL
10 mM	0.2729 mL	1.3645 mL	2.7290 mL	13.6452 mL
20 mM	0.1365 mL	0.6823 mL	1.3645 mL	6.8226 mL
50 mM	0.0546 mL	0.2729 mL	0.5458 mL	2.7290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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