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Anti-S1PR1 Antibody (4A625)
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Catalog No. TMAH-01066
Alias Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor 1, S1PR 1, S1P1, S1P receptor Edg-1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, CD antigen CD363
Anti-S1PR1 Antibody (4A625) is an antibody targeting S1PR1. Anti-S1PR1 Antibody (4A625) can be used in ELISA, WB.
Anti-S1PR1 Antibody (4A625)
Anti-S1PR1 Antibody (4A625)
😃Good
Catalog No. TMAH-01066Alias Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor 1, S1PR 1, S1P1, S1P receptor Edg-1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, CD antigen CD363
Anti-S1PR1 Antibody (4A625) is an antibody targeting S1PR1. Anti-S1PR1 Antibody (4A625) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor 1, S1PR 1, S1P1, S1P receptor Edg-1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, CD antigen CD363 |
| Ig Type | Rabbit IgG |
| Clone | 4A625 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: SH-SY5Y whole cell lysate, PC3 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, U251 whole cell lysate -All lanes: EDG1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 43 kDa -Observed band size: 43 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human EDG1 |
| Antigen Species | Human |
| Gene ID | 1901 |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Cell biology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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