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Xanthine oxidoreductase-IN-3

🥰Excellent
Catalog No. T72165Cas No. 651769-78-7

Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 of 26.3 nM, suitable for use in acute hyperuricemia studies.

Xanthine oxidoreductase-IN-3

Xanthine oxidoreductase-IN-3

🥰Excellent
Purity: 98.1%
Catalog No. T72165Cas No. 651769-78-7
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 of 26.3 nM, suitable for use in acute hyperuricemia studies.
Pack SizePriceAvailabilityQuantity
1 mg$109In Stock
5 mg$270In Stock
10 mg$383In Stock
25 mg$575In Stock
50 mg$783In Stock
100 mg$1,070In Stock
200 mg$1,450In Stock
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Batch Information

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Purity:98.1%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 of 26.3 nM, suitable for use in acute hyperuricemia studies.
Targets&IC50
XOR:26.3 nM
In vivo
Xanthine oxidoreductase-IN-3 (compound IIIa) (5 mg/kg; oral) was shown to reduce uric acid in acute hyperuricemia mice 3 h after administration.[1]
Chemical Properties
Molecular Weight299.72
FormulaC14H10ClN5O
Cas No.651769-78-7
SmilesC(NC1=CC=C(Cl)C=C1)(=O)C2=CC=C(C=C2)C=3NN=NN3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (150.14 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3364 mL16.6822 mL33.3645 mL166.8224 mL
5 mM0.6673 mL3.3364 mL6.6729 mL33.3645 mL
10 mM0.3336 mL1.6682 mL3.3364 mL16.6822 mL
20 mM0.1668 mL0.8341 mL1.6682 mL8.3411 mL
50 mM0.0667 mL0.3336 mL0.6673 mL3.3364 mL
100 mM0.0334 mL0.1668 mL0.3336 mL1.6682 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

XanthineOxidaseXanthine Oxidase
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