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Z433927330

Name: Z433927330
Brand: TargetMol
SKU: T13381
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13381Cas No. 1005883-72-6

Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).

Z433927330

🥰Excellent

Purity: 99.78%

Catalog No. T13381Cas No. 1005883-72-6

Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$93	In Stock
10 mg	$148	In Stock
25 mg	$293	In Stock
50 mg	$430	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.78%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).
Targets&IC50	AQP9 (mouse):~1.1 µM , AQP3 (mouse):~0.7 µM , AQP7 (mouse):~0.2 µM
In vitro	Z433927330 inhibits glycerol permeability(IC50 : 0.6 μM).

Chemical Properties

Molecular Weight	364.4
Formula	C₂₀H₂₀N₄O₃
Cas No.	1005883-72-6
Smiles	CCOC(=O)c1ccc(NC(=O)NCc2ccc(cc2)-n2cccn2)cc1
Relative Density.	1.23 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 280 mg/mL (768.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7442 mL	13.7212 mL	27.4424 mL	137.2119 mL
5 mM	0.5488 mL	2.7442 mL	5.4885 mL	27.4424 mL
10 mM	0.2744 mL	1.3721 mL	2.7442 mL	13.7212 mL
20 mM	0.1372 mL	0.6861 mL	1.3721 mL	6.8606 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7442 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc