N-Mal-N-bis(PEG4-NHS ester)

Name: N-Mal-N-bis(PEG4-NHS ester)
Brand: TargetMol
SKU: T16234
Rating: 4.5 (1 reviews)

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Catalog No. T16234Cas No. 2112738-60-8

N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker used for synthesizing Proteolysis Targeting Chimeras (PROTACs) [1].

N-Mal-N-bis(PEG4-NHS ester)

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Catalog No. T16234Cas No. 2112738-60-8

N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker used for synthesizing Proteolysis Targeting Chimeras (PROTACs) [1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	7-10 days	7-10 days
500 mg	Inquiry	7-10 days	7-10 days

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Product Introduction

Bioactivity

Description	N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker used for synthesizing Proteolysis Targeting Chimeras (PROTACs) [1].
In vitro	PROTACs consist of two ligands linked together; one targets an E3 ubiquitin ligase, and the other binds the target protein. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	858.84
Formula	C₃₇H₅₄N₄O₁₉
Cas No.	2112738-60-8
Smiles	C(CC(N(CCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)CCOCCOCCOCCOCCC(ON2C(=O)CCC2=O)=O)=O)N3C(=O)C=CC3=O
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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