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JNJ-42226314

🥰Excellent
Catalog No. T11724Cas No. 1252765-13-1

JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.

JNJ-42226314

JNJ-42226314

🥰Excellent
Purity: 99.62%
Catalog No. T11724Cas No. 1252765-13-1
JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$48In StockIn Stock
5 mg$113In StockIn Stock
10 mg$183In StockIn Stock
25 mg$369In StockIn Stock
50 mg$595In StockIn Stock
100 mg$953-In Stock
500 mg$1,880-In Stock
1 mL x 10 mM (in DMSO)$123In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.62%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.
In vitro
After treatment with PF-3845 ( 1 or 10 μM ), JZL-184 ( 1 or 10 μM ), JNJ-42226314 ( 1 or 10 μM ) or carrier ( DMSO ), JNJ-42226314 was selectively analyzed by competitive ABPP. The results showed that JNJ-42226314 had high selectivity for MAGL [1].
In vivo
In male C57Bl/6 mice weighing 20-30g and male Sprague-Dawley rats weighing 300-400g, treatment with JNJ-42226314 (3 mg/kg and 30 mg/kg; i.p.; 120 min) dose-dependently elevated hippocampal 2-AG levels in vivo[1].
Chemical Properties
Molecular Weight489.56
FormulaC26H24FN5O2S
Cas No.1252765-13-1
SmilesFc1ccc(cc1)-n1ccc2cc(ccc12)C(=O)N1CC(C1)N1CCN(CC1)C(=O)c1nccs1
Relative Density.1.44 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (204.26 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.21 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0427 mL10.2133 mL20.4265 mL102.1325 mL
5 mM0.4085 mL2.0427 mL4.0853 mL20.4265 mL
10 mM0.2043 mL1.0213 mL2.0427 mL10.2133 mL
20 mM0.1021 mL0.5107 mL1.0213 mL5.1066 mL
50 mM0.0409 mL0.2043 mL0.4085 mL2.0427 mL
100 mM0.0204 mL0.1021 mL0.2043 mL1.0213 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

MAGLJNJ-42226314JNJ42226314JNJ 42226314
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