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2-Aminoimidazole

Name: 2-Aminoimidazole
Brand: TargetMol
SKU: T38241
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38241Cas No. 7720-39-0

2-Aminoimidazole is a potent antimicrobial agent that effectively targets drug-resistant Mycobacterium tuberculosis by disrupting the proton motive force and blocking the electron transport chain, potentiates the action of beta-lactam antibiotics against Mycobacterium tuberculosis by decreasing the secretion of beta-lactamases and increasing the permeability of cell membranes, activates drug-resistant bacteria and improves therapeutic efficacy.

2-Aminoimidazole

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Purity: 98.05%

Catalog No. T38241Cas No. 7720-39-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.05%

Appearance:Liquid

Color:Brown

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	2-Aminoimidazole is a potent antimicrobial agent that effectively targets drug-resistant Mycobacterium tuberculosis by disrupting the proton motive force and blocking the electron transport chain, potentiates the action of beta-lactam antibiotics against Mycobacterium tuberculosis by decreasing the secretion of beta-lactamases and increasing the permeability of cell membranes, activates drug-resistant bacteria and improves therapeutic efficacy.
Targets&IC50	Arginase I (human):3.6 mM (Ki)
In vitro	Methods: Acinetobacter baumannii was treated with 2-Aminoimidazole (100 μM, 30 minutes) and live samples were observed after 30 minutes of incubation. Results: The fluorescein signal in live Acinetobacter baumannii samples was evenly distributed throughout the cell, with hot spots appearing within the cell boundaries. 2-Aminoimidazole can penetrate the membrane barrier. [1]

Chemical Properties

Molecular Weight	83.09
Formula	C₃H₅N₃
Cas No.	7720-39-0
Smiles	Nc1ncc[nH]1
Relative Density.	1.313 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (962.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (39.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	12.0351 mL	60.1757 mL	120.3514 mL	601.7571 mL
5 mM	2.4070 mL	12.0351 mL	24.0703 mL	120.3514 mL
10 mM	1.2035 mL	6.0176 mL	12.0351 mL	60.1757 mL
20 mM	0.6018 mL	3.0088 mL	6.0176 mL	30.0879 mL
50 mM	0.2407 mL	1.2035 mL	2.4070 mL	12.0351 mL
100 mM	0.1204 mL	0.6018 mL	1.2035 mL	6.0176 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc