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PIK5-12d

Name: PIK5-12d
Brand: TargetMol
SKU: T79668
Price: 249 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79668

PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer.

PIK5-12d

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Purity: 99.90%

Catalog No. T79668

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$249	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

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Product Introduction

Bioactivity

Description	PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer.
Targets&IC50	PIKfyve:1.48 nM (DC50)
In vitro	PIK5-12d is a PROTAC PIKfyve degrader with a DC50 of 1.48 nM.PIK5-12d triggers massive cytoplasmic vacuolization and inhibits autophagic flow in a wide range of prostate cancer cells, thereby inhibiting the proliferation of prostate cancer cells. [1]

Chemical Properties

Molecular Weight	973.19
Formula	C₅₂H₆₄N₁₀O₇S
Smiles	CC1=CC=CC(/C=N/NC2=NC(OCCC3=CC=C(NC(CCCCC(N[C@H](C(N4C[C@H](O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)C(C)(C)C)=O)=O)C=C3)=NC(N7CCOCC7)=C2)=C1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (164.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0275 mL	5.1377 mL	10.2755 mL	51.3774 mL
5 mM	0.2055 mL	1.0275 mL	2.0551 mL	10.2755 mL
10 mM	0.1028 mL	0.5138 mL	1.0275 mL	5.1377 mL
20 mM	0.0514 mL	0.2569 mL	0.5138 mL	2.5689 mL
50 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0275 mL
100 mM	0.0103 mL	0.0514 mL	0.1028 mL	0.5138 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc