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DDG-39
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Catalog No. T67797Cas No. 119555-47-4
Alias 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine
DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM.
DDG-39
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Purity: 99.17%
Catalog No. T67797Alias 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosineCas No. 119555-47-4
DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $189 | In Stock | In Stock | |
| 5 mg | $470 | In Stock | In Stock | |
| 10 mg | $689 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,460 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $423 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information
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Purity:99.17%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
DDG-39 AI Summary
DDG-39 exhibits significant anti-HIV activity across multiple cell lines and assays. In MT-4 cells, it inhibits HIV-1 replication with an ED50 of 9.8 µM and displays cytotoxicity with a CD50 of 117.0 µM, resulting in a Selectivity Index (SI) of 12.0. Its antiviral efficacy extends to other assays, showing an IC50 of 700.0 nM in C8166 cells against the HIV-1 RF strain and low cytotoxicity indices across various cell lines, including PBM, CEM, Vero, and 2.2.15 cells, with IC50 values exceeding 100,000.0 nM. The compound demonstrates an EC50 of 16200.0 nM in human peripheral blood mononuclear cells for HIV-1 and exhibits anti-HBV activity with an EC50 of 4000.0 nM in 2.2.15 cells. Against HIV-1 in ATH8 cells, it protects against cytopathic effects ranging from 3.0% to 56.0% at various concentrations, with minimal cytotoxicity (0.0% to 8.0%). Moreover, it significantly inhibits HIV replication in various cell types such as CEM, U937, T-cell, MO, and PBL, with ID50 values between 0.14 µg/ml and 61.8 µg/ml, and a therapeutic index (TI) of 39.0 based on HIV-induced cytopathogenesis in CEM cells. Additionally, in MT-4 cells, it shows EC50 values of 2660.0 nM (P24 antigen ELISA) and 2540.0 nM (reverse transcriptase assay) with corresponding IC50 values of 872,000.0 nM and 707,000.0 nM in MT-4 and HL60 cells, respectively, yielding high selectivity ratios (266.0 to 343.0). The compound also inhibits radiolabeled amino acid incorporation by 50% at 500.0 µM, indicating robust antiviral potential with relatively low cytotoxicity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM. |
| Synonyms | 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine |
| Molecular Weight | 229.21 |
| Formula | C9H12FN3O3 |
| Cas No. | 119555-47-4 |
| Smiles | F[C@@H]1[C@@H](O[C@H](CO)C1)N2C(=O)N=C(N)C=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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