Anti-TSHR (CT) Polyclonal Antibody

Name: Anti-TSHR (CT) Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01912
Rating: 4.5 (1 reviews)

(Synonyms: TSHR, Thyrotropin receptor, Thyroid-stimulating hormone receptor (TSH-R), LGR3) Copy Product Info

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Synonyms: TSHR, Thyrotropin receptor, Thyroid-stimulating hormone receptor (TSH-R), LGR3

Catalog No. TMAB-01912 Copy Product Info

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Anti-TSHR (CT) Polyclonal Antibody is a Rabbit antibody targeting TSHR (CT). Anti-TSHR (CT) Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-TSHR
(CT) Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-TSHR (CT) Polyclonal Antibody is a Rabbit antibody targeting TSHR (CT). Anti-TSHR (CT) Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	TSHR, Thyrotropin receptor, Thyroid-stimulating hormone receptor (TSH-R), LGR3
Ig Type	IgG
Reactivity	Human (predicted:Rat,Chicken,Pig,Cow,Horse,Rabbit,GuineaPig)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in the thyroid.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human TSHR
Antigen Species	Human
Gene Name	TSHR
Gene ID	7253
Protein Name	Thyrotropin receptor
Uniprot ID	P16473
Biology Area	Thyroid axis,Hormones
Function	Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).