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Anti-RRM2 Polyclonal Antibody
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Catalog No. TMAB-01636
Alias RRM2, RR2, Ribonucleotide Reductase Small Subunit, Ribonucleotide Reductase Small Chain, Ribonucleoside-Diphosphate Reductase Subunit M2
Anti-RRM2 Polyclonal Antibody is a Rabbit antibody targeting RRM2. Anti-RRM2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
Anti-RRM2 Polyclonal Antibody
Anti-RRM2 Polyclonal Antibody
😃Good
Catalog No. TMAB-01636Alias RRM2, RR2, Ribonucleotide Reductase Small Subunit, Ribonucleotide Reductase Small Chain, Ribonucleoside-Diphosphate Reductase Subunit M2
Anti-RRM2 Polyclonal Antibody is a Rabbit antibody targeting RRM2. Anti-RRM2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RRM2 Polyclonal Antibody is a Rabbit antibody targeting RRM2. Anti-RRM2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
| Alias | RRM2, RR2, Ribonucleotide Reductase Small Subunit, Ribonucleotide Reductase Small Chain, Ribonucleoside-Diphosphate Reductase Subunit M2 |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage. Function : Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| Immunogen | KLH conjugated synthetic peptide: human RRM2 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | p53 pathway,p53,DNA Synthesis,Nucleotide metabolism |
| Molecular Weight | Theoretical: 45 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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