Siglec-5 Protein, Human, Recombinant (His & Avi)

Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Siglec 5 is putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 324.00
500 μg	5 days	$ 1,300.00
1 mg	5 days	$ 2,170.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 324.00

500 μg

5 days

$ 1,300.00

1 mg

5 days

$ 2,170.00

Description

Species	Human
Expression System	HEK293
Tag	C-His-Avi
Accession Number	O15389
Synonyms	CD170, CD33 antigen-like 2, OBBP2, OB-BP2, Siglec5, CD33L2
Construction	Recombinant Human Siglec-5/CD170 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Glu17-Thr434.[Accession \|O15389]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 49.3 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS, 360mM NaCl (pH 7.4).
Stability & Storage	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Siglec 5 is putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.