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Lipase

Lipase refers to a class of enzymes that catalyze the hydrolysis of fats. Some lipases display a broad substrate scope including esters of cholesterol, phospholipids, and of lipid-soluble vitamins, and sphingomyelinases; however, these are usually treated separately from "conventional" lipases. Unlike esterases, which function in water, lipases "are activated only when adsorbed to an oil-water interface". Lipases perform essential roles in the digestion, transport and processing of dietary lipids in most organisms.

  • ABX-1431
    T53531446817-84-0
    ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
    • $30
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  • JJKK 048
    T156141515855-97-6In house
    JJKK 048 is a potent and selective MAGL inhibitor.
    • $30
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    TargetMol | Inhibitor Sale
  • Endothelial lipase inhibitor-1
    T111991466427-02-0In house
    Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
    • $115
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    TargetMol | Inhibitor Sale
  • Atglistatin
    T18751469924-27-3
    Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM.
    • $34
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    TargetMol | Citations Cited
  • JW 642
    T156321416133-89-5
    JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).
    • $34
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    TargetMol | Inhibitor Sale
  • XEN445
    T22491515856-92-4
    XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
    • $34
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    TargetMol | Inhibitor Sale
  • URB602
    T3591565460-15-3
    URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
    • $39
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    TargetMol | Inhibitor Sale
  • Y-320
    T1846288250-47-5
    Y-320 is a new phenylpyrazoleanilide immunomodulator.
    • $39
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  • MAGL-IN-4
    T96872135785-20-3
    MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
    • $159
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    TargetMol | Inhibitor Sale
  • AA38-3
    T937465815-76-1
    AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
    • $39
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  • JZP-430
    T156351672691-74-5
    JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
    • $101
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  • MAGL-IN-1
    T119392324160-91-8
    MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
    • $34
    5 days
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  • MJN110
    T58151438416-21-7
    MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
    • $43
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  • KML29
    T40521380424-42-9
    KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).
    • $40
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  • NG-497
    T734992598242-66-9
    NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.
    • $59
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  • Lalistat 2
    T411601234569-09-5
    Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).
    • $38
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    TargetMol | Inhibitor Sale
  • JNJ-42226314
    T117241252765-13-1
    JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.
    • $48
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  • JZL195
    T23381210004-12-8
    JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
    • $39
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  • JZL 184
    T65541101854-58-3
    JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
    • $34
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  • PF-06795071
    T164962075629-81-9
    PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
    • $2,420
    Backorder
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  • Beta-Sitosterol
    T296683-46-5
    Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.
    • $60
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  • euphol
    T5737514-47-6
    Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
    • $84
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  • JZP-361
    T277031680193-80-9
    JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
    • $64
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  • NF-1819
    T281651881244-28-5
    NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
    • $58
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  • WWL70
    T17260947669-91-2
    WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
    • $41
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