Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 722.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 |
Description | Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase. |
Targets&IC50 | HepG2:1.54 µM, SW480:37.53 µM, Hela:24.61 µM, MDA-MB-231:11.41 µM |
In vitro | In HepG2, SW480, Hela, and MDA-MB-231 cells, Tubulin inhibitor 32 (0-64 µM; 48 hours) exhibited anti-proliferative activity, with IC50 values of 1.54, 37.53, 24.61, and 11.41 µM, respectively[1]. |
In vivo | In 4-6 weeks old male nude mice (HCT-116 tumor model), Tubulin inhibitor 32 (50, 100 mg/kg; oral administration; once daily for 20 days) decreased the tumor volume and tumor weight by 44.1% and 27.0%, respectively[1]. |
Molecular Weight | 325.36 |
Formula | C18H19N3O3 |
CAS No. | 2923531-39-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tubulin inhibitor 32 2923531-39-7 Apoptosis inhibitor inhibit