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Lomerizine dihydrochloride

Name: Lomerizine dihydrochloride
Brand: TargetMol
SKU: T6571
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6571Cas No. 101477-54-7

Alias Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796

Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.

Lomerizine dihydrochloride

🥰Excellent

Purity: 99.80%

Catalog No. T6571Alias Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796Cas No. 101477-54-7

Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.

Pack Size	Price	Availability
50 mg	$31	In Stock
100 mg	$48	In Stock
500 mg	$113	In Stock
1 g	$166	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.80%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
In vitro	Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.
In vivo	Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.
Synonyms	Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796

Chemical Properties

Molecular Weight	541.46
Formula	C₂₇H₃₀F₂N₂O₃·2HCl
Cas No.	101477-54-7
Smiles	Cl.Cl.COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (27.7 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 49 mg/mL (90.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.8469 mL	9.2343 mL	18.4686 mL	92.3429 mL
5 mM	0.3694 mL	1.8469 mL	3.6937 mL	18.4686 mL
10 mM	0.1847 mL	0.9234 mL	1.8469 mL	9.2343 mL
20 mM	0.0923 mL	0.4617 mL	0.9234 mL	4.6171 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0369 mL	0.1847 mL	0.3694 mL	1.8469 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc