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Lomerizine dihydrochloride

Name: Lomerizine dihydrochloride
Brand: TargetMol
SKU: T6571
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6571Cas No. 101477-54-7

Alias Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796

Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.

Lomerizine dihydrochloride

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Purity: 99.80%

Catalog No. T6571Alias Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796Cas No. 101477-54-7

Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$48	In Stock	In Stock
500 mg	$113	In Stock	In Stock
1 g	$166	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.80%

Color:White

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COA LCMS HNMR

Product Introduction

Lomerizine dihydrochloride AI Summary

Lomerizine dihydrochloride exhibits multiple bioactivities, demonstrating significant potential in various biological contexts. It shows potency in inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1) under different assay conditions and exhibits inhibitory activity against the entry and binding of Lassa Virus, Marburg Virus, and Ebola Virus in cells. The compound also impacts the viability of several cancer cell lines including HT-29, DLD-1, GSK3B-pretreated HCT116, HCT116, SW480, SNU-C1, RKO, and Colo320, indicating its potential utility in cancer research. Additionally, Lomerizine dihydrochloride has demonstrated antifungal and antibacterial activities. It shows 2.16% inhibition against Candida albicans ATCC 90028 and 6.79% inhibition against Pseudomonas aeruginosa ATCC 27853. Notable antibacterial activity is also observed against Acinetobacter baumannii ATCC 19606 (17.33%) and Staphylococcus aureus MRSA ATCC 43300 (8.66%). However, it showed negative inhibition against Cryptococcus neoformans H99 ATCC 208821, Escherichia coli ATCC 25922, and Klebsiella pneumoniae MDR ATCC 70063. Overall, Lomerizine dihydrochloride demonstrates significant bioactivities across cancer, viral, fungal, and bacterial platforms, indicating its broad-spectrum potential in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
In vitro	Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.
In vivo	Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.
Synonyms	Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796

Chemical Properties

Molecular Weight	541.46
Formula	C₂₇H₃₀F₂N₂O₃·2HCl
Cas No.	101477-54-7
Smiles	Cl.Cl.COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (27.7 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 49 mg/mL (90.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.8469 mL	9.2343 mL	18.4686 mL	92.3429 mL
5 mM	0.3694 mL	1.8469 mL	3.6937 mL	18.4686 mL
10 mM	0.1847 mL	0.9234 mL	1.8469 mL	9.2343 mL
20 mM	0.0923 mL	0.4617 mL	0.9234 mL	4.6171 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0369 mL	0.1847 mL	0.3694 mL	1.8469 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc