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Fexaramine

Name: Fexaramine
Brand: TargetMol
SKU: T2015
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2015Cas No. 574013-66-4

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.

Fexaramine

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Purity: 99.61%

Catalog No. T2015Cas No. 574013-66-4

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$42	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$193	In Stock	In Stock
50 mg	$327	In Stock	In Stock
100 mg	$488	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Fexaramine AI Summary

Fexaramine exhibits diverse bioactivities, most notably as an agonist of the farnesoid X receptor (FXR) with an EC50 value of 25.0 nM, highlighting its potential in modulating FXR-related pathways. It also shows inhibitory activity against Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 25118.9 nM and Marburg Virus entry with a potency of 10000.0 nM. Additionally, Fexaramine demonstrates permeability characteristics suggestive of efflux transporter involvement and has been shown to inhibit SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, with an inhibition rate of 10.6%. It also shows modest inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM, with inhibition percentages ranging from 6.91% to 8.94%. Further, the compound displays varied effects on cell viability across different cell types and minor inhibitory activity against the human HDAC6 enzyme. Moreover, it affects the thermal stability of various protein domains, indicating potential interactions with protein structures..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
Targets&IC50	FXR:25 nM(EC50)

Chemical Properties

Molecular Weight	496.64
Formula	C₃₂H₃₆N₂O₃
Cas No.	574013-66-4
Smiles	COC(=O)\C=C\c1cccc(c1)N(Cc1ccc(cc1)-c1ccc(cc1)N(C)C)C(=O)C1CCCCC1
Relative Density.	1.158 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (100.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0135 mL	10.0677 mL	20.1353 mL	100.6765 mL
5 mM	0.4027 mL	2.0135 mL	4.0271 mL	20.1353 mL
10 mM	0.2014 mL	1.0068 mL	2.0135 mL	10.0677 mL
20 mM	0.1007 mL	0.5034 mL	1.0068 mL	5.0338 mL
50 mM	0.0403 mL	0.2014 mL	0.4027 mL	2.0135 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	1.0068 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc