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AST 487

🥰Excellent
Catalog No. T4053Cas No. 630124-46-8
Alias NVP-AST 487

AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

AST 487

AST 487

🥰Excellent
Purity: 99.56%
Catalog No. T4053Alias NVP-AST 487Cas No. 630124-46-8
AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31In StockIn Stock
2 mg$44In StockIn Stock
5 mg$72In StockIn Stock
10 mg$122In StockIn Stock
25 mg$197In StockIn Stock
50 mg$372In StockIn Stock
100 mg$556In StockIn Stock
500 mg$1,220-In Stock
1 mL x 10 mM (in DMSO)$84In StockIn Stock
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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]
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Purity:99.56%
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Product Introduction

Bioactivity
Description
AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
Targets&IC50
FLT3:520 nM., RET:880 nM
SynonymsNVP-AST 487
Chemical Properties
Molecular Weight529.56
FormulaC26H30F3N7O2
Cas No.630124-46-8
SmilesC(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4
Relative Density.1.341 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (94.42 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.78 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8884 mL9.4418 mL18.8836 mL94.4180 mL
5 mM0.3777 mL1.8884 mL3.7767 mL18.8836 mL
10 mM0.1888 mL0.9442 mL1.8884 mL9.4418 mL
20 mM0.0944 mL0.4721 mL0.9442 mL4.7209 mL
50 mM0.0378 mL0.1888 mL0.3777 mL1.8884 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VEGFRVascular endothelial growth factor receptorSCFRRETNVP-AST-487NVP-AST487KDRInhibitorinhibitFms like tyrosine kinase 3FLT4FLT3cRETCluster of differentiation antigen 135c-KitcKitCD135CD117Bcr-AblBcrAblAST-487AST487AST 487
Related Tags: buy AST 487 | purchase AST 487 | AST 487 cost | order AST 487 | AST 487 chemical structure | AST 487 formula | AST 487 molecular weight
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