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Lupiwighteone

Name: Lupiwighteone
Brand: TargetMol
SKU: TN1891
Price: 159 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1891Cas No. 104691-86-3

Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.

Lupiwighteone

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Purity: 98.92%

Catalog No. TN1891Cas No. 104691-86-3

Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$159	In Stock	In Stock
5 mg	$397	In Stock	In Stock
10 mg	$589	In Stock	In Stock
25 mg	$945	In Stock	In Stock
50 mg	$1,280	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$570	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.

In vitro

This study aimed to examine the antitumor activity of Lupiwighteone, explore its antitumor mechanism in a human prostate carcinoma cell line (DU-145), and evaluate its antiangiogenetic activity in the human umbilical vein endothelial cell line (HUVEC). The results showed that Lupiwighteone could inhibit the growth of DU-145 and HUVEC cells in a concentration-dependent and time-dependent manner by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Flow cytometry analysis indicated that Lupiwighteone could induce cell cycle arrest, cells apoptosis, mitochondrial membrane potential loss, and an increase in intracellular reactive oxygen species of DU-145 cells. Upregulation of Bax, cytochrome c, caspase-3, and PARP-1 protein expressions and downregulation of Bcl-2, procaspase-9, and p-Akt protein expressions were observed by western blot after the treatment of Lupiwighteone. Furthermore, the effects of Lupiwighteone on the cellular behavior of HUVECs were also investigated.

Chemical Properties

Molecular Weight	338.35
Formula	C₂₀H₁₈O₅
Cas No.	104691-86-3
Smiles	CC(C)=CCc1c(O)cc(O)c2c1occ(-c1ccc(O)cc1)c2=O
Relative Density.	1.351 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (177.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9555 mL	14.7776 mL	29.5552 mL	147.7760 mL
5 mM	0.5911 mL	2.9555 mL	5.9110 mL	29.5552 mL
10 mM	0.2956 mL	1.4778 mL	2.9555 mL	14.7776 mL
20 mM	0.1478 mL	0.7389 mL	1.4778 mL	7.3888 mL
50 mM	0.0591 mL	0.2956 mL	0.5911 mL	2.9555 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4778 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc