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ML353 (Synonyms: VU0478006)

Name: ML353
Brand: TargetMol
SKU: T67917
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T67917 Copy Product Info

Purity: 99.98%

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ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.

ML353

Copy Product Info

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Catalog No. T67917

Synonyms VU0478006

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Pack Size	Price	USA Stock	Global Stock
5 mg	$45	-	In Stock
10 mg	$72	-	In Stock
25 mg	$123	-	In Stock
50 mg	$167	-	In Stock
100 mg	$243	-	In Stock
200 mg	$331	-	In Stock
1 mL x 10 mM (in DMSO)	$48	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.
Targets&IC50	mGlu5:18.2 nM (Ki)
In vitro	ML353 is a highly soluble compound with a solubility of 16.9 µM or 6.0 µg/mL (pH=7.4) in PBS. ML353 demonstrates excellent stability in PBS buffer.[1]
Synonyms	VU0478006

Chemical Properties

Molecular Weight	306.33
Formula	C₁₉H₁₅FN₂O
Smiles	O=C(C1=NC=C(C#CC2=CC(F)=CC=C2)C=C1)N1CC2CC2C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (81.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2645 mL	16.3223 mL	32.6445 mL	163.2227 mL
5 mM	0.6529 mL	3.2645 mL	6.5289 mL	32.6445 mL
10 mM	0.3264 mL	1.6322 mL	3.2645 mL	16.3223 mL
20 mM	0.1632 mL	0.8161 mL	1.6322 mL	8.1611 mL
50 mM	0.0653 mL	0.3264 mL	0.6529 mL	3.2645 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc