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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $106 | In Stock | |
10 mg | $173 | In Stock | |
25 mg | $293 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $581 | In Stock | |
500 mg | $1,150 | In Stock | |
1 mL x 10 mM (in DMSO) | $113 | In Stock |
Description | ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo. |
Targets&IC50 | mGlu5:18.2 nM (Ki) |
In vitro | ML353 is a highly soluble compound with a solubility of 16.9 µM or 6.0 µg/mL (pH=7.4) in PBS. ML353 demonstrates excellent stability in PBS buffer.[1] |
Alias | VU0478006 |
Molecular Weight | 306.33 |
Formula | C19H15FN2O |
Cas No. |
Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (81.61 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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