Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) of the silence-allosteric regulator (SAM) of mGlu5. ML353 increased the affinity of common allosteric sites, much higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential as a compound to address intrinsic activity or drug blocking in SAM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 178.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 489.00 | |
50 mg | In stock | $ 686.00 | |
100 mg | In stock | $ 969.00 | |
500 mg | In stock | $ 1,930.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 189.00 |
Description | ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) of the silence-allosteric regulator (SAM) of mGlu5. ML353 increased the affinity of common allosteric sites, much higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential as a compound to address intrinsic activity or drug blocking in SAM. |
Targets&IC50 | mGlu5:18.2 nM (Ki) |
In vitro | ML353 is a highly soluble compound with a solubility of 16.9 µM or 6.0 µg/mL (pH=7.4) in PBS. ML353 demonstrates excellent stability in PBS buffer.[1] |
Synonyms | VU0478006 |
Molecular Weight | 306.33 |
Formula | C19H15FN2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (81.61 mM)
You can also refer to dose conversion for different animals. More
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ML353 Membrane transporter/Ion channel Potassium Channel VU 0478006 ML-353 ML 353 VU-0478006 VU0478006 inhibitor inhibit