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ML353

ML353
ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.
Catalog No. T67917
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Purity:99.82%
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ML353

Catalog No. T67917
ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.
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Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$106In Stock
10 mg$173In Stock
25 mg$293In Stock
50 mg$397In Stock
100 mg$581In Stock
500 mg$1,150In Stock
1 mL x 10 mM (in DMSO)$113In Stock
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Product Introduction

Bioactivity
Description
ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.
Targets&IC50
mGlu5:18.2 nM (Ki)
In vitro
ML353 is a highly soluble compound with a solubility of 16.9 µM or 6.0 µg/mL (pH=7.4) in PBS. ML353 demonstrates excellent stability in PBS buffer.[1]
AliasVU0478006
Chemical Properties
Molecular Weight306.33
FormulaC19H15FN2O
Cas No.
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (81.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2645 mL16.3223 mL32.6445 mL163.2227 mL
5 mM0.6529 mL3.2645 mL6.5289 mL32.6445 mL
10 mM0.3264 mL1.6322 mL3.2645 mL16.3223 mL
20 mM0.1632 mL0.8161 mL1.6322 mL8.1611 mL
50 mM0.0653 mL0.3264 mL0.6529 mL3.2645 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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