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(-)-Maackiain

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Catalog No. TN1901Cas No. 2035-15-6

(-)-Maackiain is a natural anti-inflammatory agent that inhibits histamine H1 receptor and IL-4 gene transcription upregulation, suppresses PKCδ activation, activates the caspase-1 pathway, and promotes IL-1β production.

(-)-Maackiain
Other Forms of (-)-Maackiain:

(-)-Maackiain

😃Good
Purity: 99.95%
Catalog No. TN1901Cas No. 2035-15-6
(-)-Maackiain is a natural anti-inflammatory agent that inhibits histamine H1 receptor and IL-4 gene transcription upregulation, suppresses PKCδ activation, activates the caspase-1 pathway, and promotes IL-1β production.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$52-In Stock
5 mg$113-In Stock
10 mg$193-In Stock
25 mg$375-In Stock
50 mg$552-In Stock
100 mg$787-In Stock
1 mL x 10 mM (in DMSO)$109-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.95%
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Product Introduction

Bioactivity
Description
(-)-Maackiain is a natural anti-inflammatory agent that inhibits histamine H1 receptor and IL-4 gene transcription upregulation, suppresses PKCδ activation, activates the caspase-1 pathway, and promotes IL-1β production.
In vitro
(-)-Maackiain (0-30 µM, 24 hours) inhibits PMA-induced histamine H1 receptor expression in HeLa cells, while also suppressing PMA-induced phosphorylation of PKCδ at tyrosine residue 311 and preventing PKCδ translocation to the Golgi apparatus [3]. (-)-Maackiain (0-30 µM, 24 hours) suppresses DNP-HSA (antigen)-stimulated IL-4 gene expression in RBL-2H3 cells [3].
In vivo
(-)-Maackiain (5-20 mg/kg, po, once daily for 3 weeks) exhibited anti-allergic activity in a TDI-induced nasal allergy mouse model, alleviating symptoms such as sneezing, nasal mucosal swelling, nasal redness, and rhinorrhea [3].
Chemical Properties
Molecular Weight284.26
FormulaC16H12O5
Cas No.2035-15-6
SmilesOC=1C=C2C([C@]3([C@](C=4C(O3)=CC5=C(C4)OCO5)(CO2)[H])[H])=CC1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (281.43 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5179 mL17.5895 mL35.1791 mL175.8953 mL
5 mM0.7036 mL3.5179 mL7.0358 mL35.1791 mL
10 mM0.3518 mL1.7590 mL3.5179 mL17.5895 mL
20 mM0.1759 mL0.8795 mL1.7590 mL8.7948 mL
50 mM0.0704 mL0.3518 mL0.7036 mL3.5179 mL
100 mM0.0352 mL0.1759 mL0.3518 mL1.7590 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

( ​)​ Maackiain
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