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IL-17RE Protein, Mouse, Recombinant (His)

IL-17RE Protein, Mouse, Recombinant (His)
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IL-17RE Protein, Mouse, Recombinant (His)

Catalog No. TMPJ-01208
IL-17RE Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-42 KDa and the accession number is Q8BH06.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
10 μg$1077-10 days
50 μg$3247-10 days
500 μg$1,9507-10 days
1 mg$2,9407-10 days
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Biological Description

Description
IL-17RE Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-42 KDa and the accession number is Q8BH06.
Species
Mouse
Expression System
HEK293 Cells
TagC-6xHis
Accession NumberQ8BH06
Synonyms
interleukin 17 receptor E,IL-17 receptor E,IL-17RE,IL17RE,IL-17 RE
Amino Acid
Ala115-His414
Construction
Ala115-His414
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight38-42 KDa (reducing condition)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
Interleukin 17 Receptor E (IL 17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL 17 receptors. IL 17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma /δ T cells. It associates with the widely expressed IL 17 RA to form a heterodimeric receptor for IL-17C. IL-17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. IL 17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is up regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). IL 17 RE is reciprocally down regulated in psoriatic lesions. The interaction of IL 17C with IL 17 RE promotes mucosal immunity through the induction of anti bacterial peptides and pro inflammatory cytokines and chemokines. IL 17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis. IL 17C is additionally up regulated in Th17 cell dependent autoimmunity. In this setting, it exacerbates disease severity by inducing Th17 cell production of IL 17A, IL 17F, IL 22, CCR6, and CCL20. The up regulation of IL 17 RE in hepatocellular carcinoma is associated with poor prognosis.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.