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ARP-100

🥰Excellent
Catalog No. T14322Cas No. 704888-90-4
Alias MMP-2 Inhibitor III

ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM) and MMP-9 (0.2 μM)[1][2].

ARP-100

ARP-100

🥰Excellent
Purity: 97.18%
Catalog No. T14322Alias MMP-2 Inhibitor IIICas No. 704888-90-4
ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM) and MMP-9 (0.2 μM)[1][2].
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$64In Stock
10 mg$98In Stock
25 mg$198In Stock
50 mg$372In Stock
100 mg$597In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Purity:97.18%
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Product Introduction

Bioactivity
Description
ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM) and MMP-9 (0.2 μM)[1][2].
Targets&IC50
MMP2:12 nM, MMP7:>50 μM, MMP9:0.2 μM, MMP1:>50 μM, MMP3:4.5 μM
In vitro
ARP-100 (50 nM) exhibits a significant reduction in the total number of invasive elongations[1].
SynonymsMMP-2 Inhibitor III
Chemical Properties
Molecular Weight364.42
FormulaC17H20N2O5S
Cas No.704888-90-4
SmilesCC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 96 mg/mL (263.43 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7441 mL13.7204 mL27.4409 mL137.2043 mL
5 mM0.5488 mL2.7441 mL5.4882 mL27.4409 mL
10 mM0.2744 mL1.3720 mL2.7441 mL13.7204 mL
20 mM0.1372 mL0.6860 mL1.3720 mL6.8602 mL
50 mM0.0549 mL0.2744 mL0.5488 mL2.7441 mL
100 mM0.0274 mL0.1372 mL0.2744 mL1.3720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

selectiveMMP-9MMP-7MMP-3MMP-2MMP-1MMPmetalloproteinaseMatrix metalloproteinasesmatrixmatrigelinvasionInhibitorinhibitARP-100ARP100ARP 100anti-invasive
Related Tags: buy ARP-100 | purchase ARP-100 | ARP-100 cost | order ARP-100 | ARP-100 chemical structure | ARP-100 in vitro | ARP-100 formula | ARP-100 molecular weight
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