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4-(2-Azidoethyl)phenol
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Catalog No. T206147 Copy Product Info
Purity: 98.86%
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4-(2-Azidoethyl)phenol is a bifunctional small molecule probe featuring both a phenolic hydroxyl group and an azide structure. Its core application lies in the phenol moiety serving as a substrate for APEX2 (ascorbate peroxidase), generating reactive radicals in situ in the presence of H₂O₂ to label neighboring proteins. Concurrently, the terminal azide group can be linked to alkyne-labeled detection molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) to achieve biotinylation or fluorescence visualization. 4-(2-Azidoethyl)phenol is widely used in proximity labeling-based proteomics research.
Cas No. 74447-34-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $55 | - | In Stock | |
| 5 mg | $129 | - | In Stock | |
| 10 mg | $198 | - | In Stock | |
| 25 mg | $335 | - | In Stock | |
| 50 mg | $463 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.86%
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-(2-Azidoethyl)phenol is a bifunctional small molecule probe featuring both a phenolic hydroxyl group and an azide structure. Its core application lies in the phenol moiety serving as a substrate for APEX2 (ascorbate peroxidase), generating reactive radicals in situ in the presence of H₂O₂ to label neighboring proteins. Concurrently, the terminal azide group can be linked to alkyne-labeled detection molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) to achieve biotinylation or fluorescence visualization. 4-(2-Azidoethyl)phenol is widely used in proximity labeling-based proteomics research. |
| In vitro | 4-(2-Azidoethyl)phenol exhibits moderate and stable RNA labeling activity in an in vitro APEX2-mediated proximity labeling system [1]. 4-(2-Azidoethyl)phenol (2 mM; 15 min pre-incubation + 3 min H₂O₂ treatment) exhibits strong RNA labeling efficiency in live HEK 293T cells expressing mito-APEX2, outperforming most tested APEX2 probes and being second only to Ph_yne [1]. 4-(2-Azidoethyl)phenol (2 mM; 15 min pre-incubation + 3 min H₂O₂ treatment) can highly specifically enrich mitochondrially encoded RNA from HEK 293T cells expressing mito-APEX2 via CuAAC- and SPAAC-mediated biotinylation, with minimal enrichment of cytoplasmic GAPDH mRNA [1]. 4-(2-Azidoethyl)phenol (2 mM; 15 min pre-incubation + 3 min H₂O₂ treatment) enables high-sensitivity, high-specificity enrichment of mitochondrial-encoded RNA across the entire transcriptome in HEK 293T cells expressing mito-APEX2, without significantly enriching cytoplasmic RNA [1]. |
| Molecular Weight | 163.18 |
| Formula | C8H9N3O |
| Cas No. | 74447-34-0 |
| Smiles | [N-]=[N+]=NCCC1=CC=C(O)C=C1 |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (490.26 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Related Tags: 4-(2-Azidoethyl)phenol chemical structure | 4-(2-Azidoethyl)phenol in vitro | 4-(2-Azidoethyl)phenol formula | 4-(2-Azidoethyl)phenol molecular weight
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