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M190S

Catalog No. T79747 CAS 2578300-07-7

M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo. It shows promise as a research tool for probing cell death mechanisms and could lead to the development of therapeutics that target the mitochondria-dependent cell death pathway. M109S possesses oral bioactivity and excellent brain permeability [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

M190S, CAS 2578300-07-7

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,670.00
50 mg	8-10 weeks	$ 2,180.00
100 mg	8-10 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo. It shows promise as a research tool for probing cell death mechanisms and could lead to the development of therapeutics that target the mitochondria-dependent cell death pathway. M109S possesses oral bioactivity and excellent brain permeability [1].
Targets&IC50	Caspase-3:23.4 nM (EC50)
In vitro	M109S, at concentrations ranging from 0.1 to 10,000 nM over 24 to 48 hours, inhibits Bax- and Bak-induced apoptosis [1]. Additionally, M109S at 0 to 10 μM for 4 hours suppresses Staurosporine-induced apoptosis in MEF cells. It also prevents apoptosis in Neuro2a cells initiated by Etoposide when applied at 0 to 10μM for 24 hours [1]. At a concentration of 500 nM for 24 hours, M109S inhibits Obatoclax-induced apoptosis in ARPE19 cells [1]. Furthermore, at 500 nM for 48 hours, M109S inhibits Bax conformational change (N-terminus exposure) and mitochondrial translocation [1]. At 1.0 μM for 4 hours, M109S reduces mitochondrial oxygen consumption and reactive oxygen species, while M109S at 0.1 to 1 nM for 4 hours increases glycolysis [1].
In vivo	M109S, administered at a dose of 10 mg/kg through oral gavage three times within 48 hours, protects the retina from photoreceptor cell death induced by intense light exposure [1]. As an orally bioactive cell death inhibitor that penetrates the blood-brain/retinal barrier, M109S can be delivered via intraperitoneal injection at 1 mg/kg, intravenous injection at 5 mg/kg, or oral gavage at 10 mg/kg in a single dose [1].

Molecular Weight	375.42
Formula	C21H21N5O2
CAS No.	2578300-07-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

M190S 2578300-07-7 Apoptosis Proteases/Proteasome Caspase inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.