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ACHM-025

Name: ACHM-025
Brand: TargetMol
SKU: T213301
Rating: 4.5 (1 reviews)

Catalog No. T213301 Copy Product Info

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ACHM-025 is a prodrug that is selectively activated by AKR1C3 into a nitrogen mustard DNA alkylating agent. It can be used in cancer research, including studies on leukemia.

ACHM-025

Copy Product Info

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Catalog No. T213301

ACHM-025 is a prodrug that is selectively activated by AKR1C3 into a nitrogen mustard DNA alkylating agent. It can be used in cancer research, including studies on leukemia.

ACHM-025

Cas No. 2377718-85-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	ACHM-025 is a prodrug that is selectively activated by AKR1C3 into a nitrogen mustard DNA alkylating agent. It can be used in cancer research, including studies on leukemia.
In vitro	ACHM-025 exhibits potent cytotoxicity specifically in HCT116 cells overexpressing AKR1C3, with an IC50 value of 0.03 μM.
In vivo	ACHM-025 (25 mg/kg, administered intraperitoneally on days 0, 7, and 14) significantly reduces the proportion of human leukemia cells in peripheral blood and extends the survival of female NOD/SCID or NSG mice implanted with chemotherapy-resistant T-ALL PDX (ALL-31).

Chemical Properties

Molecular Weight	544.61
Formula	C₁₇H₂₈N₄O₁₀S₃
Cas No.	2377718-85-7
Smiles	O=N(=O)C1=CC=C(C(=C1)S(=O)(=O)N2CCN(C)CC2)N(CCOS(=O)(=O)C)CCOS(=O)(=O)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc