Shopping Cart

Your shopping cart is currently empty

Proceed to checkout Continue shopping

RLX-33

Copy Product Info

😃Good

Catalog No. T62929Cas No. 2784577-71-3

RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats.RLX-33 can be used to study the metabolic syndrome.

RLX-33

Copy Product Info

😃Good

Purity: 99.89%

Catalog No. T62929Cas No. 2784577-71-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$75	In Stock	In Stock
5 mg	$187	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$475	In Stock	In Stock
50 mg	$678	In Stock	In Stock
100 mg	$912	In Stock	In Stock
500 mg	$1,780	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

RLX-33 AI Summary

RLX-33 is a multi-target agent with diverse bioactivities. It exhibits an efflux ratio of 1.0 in MDCK-MDR1 cells and shows antagonist activity at human RXFP3 with IC50 values of 3080.0 nM and 4520.0 nM, while its activity as an antagonist at human RXFP4 is below 30.0%. The compound has different pharmacokinetic parameters in Wistar rat plasma and brain, including Cmax, Tmax, AUC, half-life, and unbound clearance. It demonstrates a Papp value of 1.3 x 10^-6 cm/s across the apical to basolateral sides in MDCK-MDR1 cells and exhibits low kinetic aqueous solubility (< 1000.0 nM). Additionally, it has high plasma protein binding at 99.8% in Wistar rats. RLX-33 also inhibits a range of receptors, including sigma-2, sigma-1, 5HT2C, muscarinic, opioid, serotonin, adrenergic, DAT, NET, SERT, GABAA, histamine, and PBR receptors, with inhibition levels below 50%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats.RLX-33 can be used to study the metabolic syndrome.
Targets&IC50	RXFP3:2.36 μM

Chemical Properties

Molecular Weight	462.89
Formula	C₂₄H₁₉ClN₄O₄
Cas No.	2784577-71-3
Smiles	N(C(=O)C1CN(CC2=CC=CO2)C(=O)C1)C3=CC=C(C4=NC(=NO4)C5=CC=C(Cl)C=C5)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (243.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1603 mL	10.8017 mL	21.6034 mL	108.0170 mL
5 mM	0.4321 mL	2.1603 mL	4.3207 mL	21.6034 mL
10 mM	0.2160 mL	1.0802 mL	2.1603 mL	10.8017 mL
20 mM	0.1080 mL	0.5401 mL	1.0802 mL	5.4009 mL
50 mM	0.0432 mL	0.2160 mL	0.4321 mL	2.1603 mL
100 mM	0.0216 mL	0.1080 mL	0.2160 mL	1.0802 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc