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Tepotinib hydrochloride(1 : x)

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Catalog No. T9601Cas No. 1103508-80-0

Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.

Tepotinib hydrochloride(1 : x)
Other Forms of Tepotinib hydrochloride(1 : x):
TepotinibT61211100598-32-0
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Tepotinib hydrochloride(1 : x)

🥰Excellent
Purity: 99.81%
Catalog No. T9601Cas No. 1103508-80-0
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$148-In Stock
5 mg$336-In Stock
10 mg$497-In Stock
25 mg$793-In Stock
50 mg$1,130-In Stock
1 mL x 10 mM (in DMSO)$423-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.81%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
In vitro
Tepotinib hydrochloride(1 : x) potently inhibits ABCB1 and ABCG2 efflux transporters, which was confirmed by molecular docking. In addition, Tepotinib hydrochloride(1 : x) inhibited several recombinant cytochrome P450 (CYP) isoforms with varying potency. Tepotinib hydrochloride(1 : x) synergistically reversed daunorubicin and mitoxantrone resistance in cells with ABCB1 and ABCG2 overexpression, respectively[2].
Chemical Properties
Molecular Weight529.04
FormulaC29H29ClN6O2
Cas No.1103508-80-0
SmilesCl.CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (94.51 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8902 mL9.4511 mL18.9022 mL94.5108 mL
5 mM0.3780 mL1.8902 mL3.7804 mL18.9022 mL
10 mM0.1890 mL0.9451 mL1.8902 mL9.4511 mL
20 mM0.0945 mL0.4726 mL0.9451 mL4.7255 mL
50 mM0.0378 mL0.1890 mL0.3780 mL1.8902 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Tepotinib hydrochloride(1 : x)PgpMetHGFRcMet/HGFRc-MetcMetABCG2ABCB1
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