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CPDA

Name: CPDA
Brand: TargetMol
SKU: T10877
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10877Cas No. 1415834-63-7

CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).

CPDA

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Purity: 98.34%

Catalog No. T10877Cas No. 1415834-63-7

CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$135	In Stock	In Stock
50 mg	$227	In Stock	In Stock
100 mg	$358	In Stock	In Stock
200 mg	$492	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.34%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
In vitro	CPDA enhances insulin signaling. CPDA was found to enhance in vitro insulin signaling through the Akt pathway more efficiently than the previously reported SHIP2 inhibitor AS1949490, and ameliorated abnormal glucose metabolism in diabetic (db/db) mice.
In vivo	CPDA significantly enhances abnormal glucose metabolism in diabetic animals, as evidenced by its effectiveness in improving glucose metabolism in db/db mice.

Chemical Properties

Molecular Weight	388.8
Formula	C₂₀H₁₅ClF₂N₂O₂
Cas No.	1415834-63-7
Smiles	Fc1cccc(F)c1CC(=O)Nc1cc(OCc2ccc(Cl)cc2)ccn1
Relative Density.	1.381 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5720 mL	12.8601 mL	25.7202 mL	128.6008 mL
5 mM	0.5144 mL	2.5720 mL	5.1440 mL	25.7202 mL
10 mM	0.2572 mL	1.2860 mL	2.5720 mL	12.8601 mL
20 mM	0.1286 mL	0.6430 mL	1.2860 mL	6.4300 mL
50 mM	0.0514 mL	0.2572 mL	0.5144 mL	2.5720 mL
100 mM	0.0257 mL	0.1286 mL	0.2572 mL	1.2860 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc