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Eribulin (Synonyms: ER-086526, E7389, B1939)

Name: Eribulin
Brand: TargetMol
SKU: T13688
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T13688 Copy Product Info

Purity: 99.96%

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Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.

Eribulin

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Catalog No. T13688

Synonyms ER-086526, E7389, B1939

Cas No. 253128-41-5

Pack Size	Price	USA Stock	Global Stock
500 μg	$98	In Stock	In Stock
1 mg	$157	In Stock	In Stock
5 mg	$396	In Stock	In Stock
10 mg	$635	In Stock	In Stock
25 mg	$1,130	In Stock	In Stock
50 mg	$1,580	In Stock	In Stock
100 mg	$2,220	-	In Stock
1 mL x 10 mM (in DMSO)	$638	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
In vitro	In LM8 and Dunn cells, Eribulin inhibited cell proliferation in a dose-dependent manner at concentrations of 0, 1, 10, and 100 nM for 72 hours[1].
In vivo	In 4-week-old C3H/HeN mice injected with LM8 cells, Eribulin (1 mg/kg; intravenous injection, once a week for 2 weeks) suppressed primary tumor growth and induced apoptosis in tumor cells. It also reduced the occurrence of lung metastasis and led to a decrease in body weight[1].
Synonyms	ER-086526, E7389, B1939

Chemical Properties

Molecular Weight	729.90
Formula	C₄₀H₅₉NO₁₁
Cas No.	253128-41-5
Smiles	[H][C@@]12CC(=C)[C@]([H])(CC[C@@]3([H])C[C@@H](C)C(=C)[C@@]([H])(C[C@]4([H])O[C@H](C[C@H](O)CN)[C@H](OC)[C@@]4([H])CC(=O)C[C@@]4([H])CC[C@]5([H])O[C@@]6([H])[C@@]7([H])O[C@@]8(C[C@@]7([H])O[C@@]6([H])[C@@]([H])(O8)[C@@]5([H])O4)CC1)O3)O2
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (68.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3701 mL	6.8503 mL	13.7005 mL	68.5025 mL
5 mM	0.2740 mL	1.3701 mL	2.7401 mL	13.7005 mL
10 mM	0.1370 mL	0.6850 mL	1.3701 mL	6.8503 mL
20 mM	0.0685 mL	0.3425 mL	0.6850 mL	3.4251 mL
50 mM	0.0274 mL	0.1370 mL	0.2740 mL	1.3701 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc