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Eribulin

Name: Eribulin
Brand: TargetMol
SKU: T13688
Price: 283 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13688Cas No. 253128-41-5

Alias ER-086526, E7389, B1939

Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.

Eribulin

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Purity: 99.96%

Catalog No. T13688Alias ER-086526, E7389, B1939Cas No. 253128-41-5

Pack Size	Price	Availability
500 μg	$283	In Stock
1 mg	$347	In Stock
5 mg	$513	In Stock
10 mg	$828	In Stock
25 mg	$1,230	In Stock
50 mg	$1,650	In Stock
100 mg	$2,220	In Stock
1 mL x 10 mM (in DMSO)	$798	In Stock

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Batch Information

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Purity:99.96%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
In vitro	In LM8 and Dunn cells, Eribulin inhibited cell proliferation in a dose-dependent manner at concentrations of 0, 1, 10, and 100 nM for 72 hours[1].
In vivo	In 4-week-old C3H/HeN mice injected with LM8 cells, Eribulin (1 mg/kg; intravenous injection, once a week for 2 weeks) suppressed primary tumor growth and induced apoptosis in tumor cells. It also reduced the occurrence of lung metastasis and led to a decrease in body weight[1].
Synonyms	ER-086526, E7389, B1939

Chemical Properties

Molecular Weight	729.90
Formula	C₄₀H₅₉NO₁₁
Cas No.	253128-41-5
Smiles	[H][C@@]12CC(=C)[C@]([H])(CC[C@@]3([H])C[C@@H](C)C(=C)[C@@]([H])(C[C@]4([H])O[C@H](C[C@H](O)CN)[C@H](OC)[C@@]4([H])CC(=O)C[C@@]4([H])CC[C@]5([H])O[C@@]6([H])[C@@]7([H])O[C@@]8(C[C@@]7([H])O[C@@]6([H])[C@@]([H])(O8)[C@@]5([H])O4)CC1)O3)O2
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (137.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3701 mL	6.8503 mL	13.7005 mL	68.5025 mL
5 mM	0.2740 mL	1.3701 mL	2.7401 mL	13.7005 mL
10 mM	0.1370 mL	0.6850 mL	1.3701 mL	6.8503 mL
20 mM	0.0685 mL	0.3425 mL	0.6850 mL	3.4251 mL
50 mM	0.0274 mL	0.1370 mL	0.2740 mL	1.3701 mL
100 mM	0.0137 mL	0.0685 mL	0.1370 mL	0.6850 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc