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Eribulin

Eribulin
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Eribulin

Catalog No. T13688Cas No. 253128-41-5
Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
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Pack SizePriceAvailabilityQuantity
1 mg$420In Stock
5 mg$596In Stock
10 mg$828In Stock
25 mg$1,410In Stock
50 mg$2,115In Stock
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Product Introduction

Bioactivity
Description
Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
In vitro
In LM8 and Dunn cells, Eribulin inhibited cell proliferation in a dose-dependent manner at concentrations of 0, 1, 10, and 100 nM for 72 hours[1].
In vivo
In 4-week-old C3H/HeN mice injected with LM8 cells, Eribulin (1 mg/kg; intravenous injection, once a week for 2 weeks) suppressed primary tumor growth and induced apoptosis in tumor cells. It also reduced the occurrence of lung metastasis and led to a decrease in body weight[1].
AliasER-086526, E7389, B1939
Chemical Properties
Molecular Weight729.90
FormulaC40H59NO11
Cas No.253128-41-5
Storage & Solubility Information
Storagestore at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (137.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3701 mL6.8503 mL13.7005 mL68.5025 mL
5 mM0.2740 mL1.3701 mL2.7401 mL13.7005 mL
10 mM0.1370 mL0.6850 mL1.3701 mL6.8503 mL
20 mM0.0685 mL0.3425 mL0.6850 mL3.4251 mL
50 mM0.0274 mL0.1370 mL0.2740 mL1.3701 mL
100 mM0.0137 mL0.0685 mL0.1370 mL0.6850 mL

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