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1-Deoxymannojirimycin hydrochloride
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Catalog No. T22468Cas No. 73465-43-7
1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.
1-Deoxymannojirimycin hydrochloride
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Catalog No. T22468Cas No. 73465-43-7
1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | 35 days | 35 days | |
| 5 mg | $297 | 35 days | 35 days | |
| 10 mg | $456 | 35 days | 35 days | |
| 25 mg | $758 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Storage & Solubility Information
| Description | 1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity. |
| Targets&IC50 | α1/2 mannosidase I:20 μM |
| In vitro | Exposure of such mutant virus strains to 1-Deoxymannojirimycin results in an enhanced suppression of mutant virus-induced cytopathicity in CEM cell cultures[1].When combined with CBAs at concentrations that showed poor if any suppression of mutant virus replication as single drugs, a synergistic antiviral activity of 1-Deoxymannojirimycin was observed[1]. |
| Molecular Weight | 199.63 |
| Formula | C6H14ClNO4 |
| Cas No. | 73465-43-7 |
| Smiles | Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (100.19 mM), Sonication is recommended. H2O: 20 mg/mL (100.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (10.02 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α1,2-mannosidase Iα1,2-mannosidasereticulumN-linkedInhibitorinhibitInfluenzaVirusInfluenza virusHuman immunodeficiency virusHIVProteaseHIV-1HIV ProteaseHIVglycosylationEndoplasmicantiviral1-Deoxymannojirimycin Hydrochloride1Deoxymannojirimycin hydrochloride1-Deoxymannojirimycin1 Deoxymannojirimycin hydrochloride
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