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YZ9

Name: YZ9
Brand: TargetMol
SKU: T23552
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23552Cas No. 6093-71-6

Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, acting as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].

YZ9

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Purity: 99.59%

Catalog No. T23552Cas No. 6093-71-6

Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, acting as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$37	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$70	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, acting as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].
Targets&IC50	PFKFB3:0.183 µM
In vitro	Y29 inhibits the HeLa cell growth with a GI50 of 2.7 μM[1].

Chemical Properties

Molecular Weight	234.2
Formula	C₁₂H₁₀O₅
Cas No.	6093-71-6
Smiles	CCOC(=O)c1cc2ccc(O)cc2oc1=O
Relative Density.	1.397 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (85.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2699 mL	21.3493 mL	42.6985 mL	213.4927 mL
5 mM	0.8540 mL	4.2699 mL	8.5397 mL	42.6985 mL
10 mM	0.4270 mL	2.1349 mL	4.2699 mL	21.3493 mL
20 mM	0.2135 mL	1.0675 mL	2.1349 mL	10.6746 mL
50 mM	0.0854 mL	0.4270 mL	0.8540 mL	4.2699 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc