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sbp-7455

Name: sbp-7455
Brand: TargetMol
SKU: T8850
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8850Cas No. 1884222-74-5

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.

sbp-7455

🥰Excellent

Purity: 99.842%

Catalog No. T8850Cas No. 1884222-74-5

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.

Pack Size	Price	Availability
1 mg	$59	In Stock
5 mg	$121	In Stock
10 mg	$202	In Stock
25 mg	$364	In Stock
50 mg	$594	In Stock
100 mg	$745	In Stock

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Purity:99.842%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
Targets&IC50	Autophagy:0.3 μM, ULK2:476 nM, ULK1:13 nM
In vitro	SBP-7455 treatment inhibits cell growth with an IC50 of 0.3 μM for MDA-MB-468 cells. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells that are dependent on autophagy for survival[1].
In vivo	To evaluate the PD profile and in vivo target engagement, mice were dosed with SBP-7455 (10 mg/kg) or vehicle by oral gavage, and liver samples were collected after 2 h.Based on the PK and PD profiles, our data show that SBP-7455 is an efficacious tool that can be used to modulate autophagy in vivop[1].

Chemical Properties

Molecular Weight	354.33
Formula	C₁₆H₁₇F₃N₄O₂
Cas No.	1884222-74-5
Smiles	COc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1OC
Relative Density.	1.405 g/cm3 (Predicted)
Color	Purple
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (338.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8222 mL	14.1111 mL	28.2223 mL	141.1114 mL
5 mM	0.5644 mL	2.8222 mL	5.6445 mL	28.2223 mL
10 mM	0.2822 mL	1.4111 mL	2.8222 mL	14.1111 mL
20 mM	0.1411 mL	0.7056 mL	1.4111 mL	7.0556 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8222 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc